NFL: Tennessee Titans at Jacksonville Jaguars
Reinhold Matay / USA TODAY Sports

The Jacksonville Jaguars and the Tennessee Titans are set to square off in an AFC South matchup at 1 p.m. ET on Sunday at Nissan Stadium. The Titans won their season opener by two points and the Jaguars won their first game by seven points. Tennessee is favored by 8.5 points in the latest Titans vs. Jaguars odds from William Hill, and the over-under is set at 42.5. Before entering any Jaguars vs. Titans picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,400 for $100 players on its top-rated NFL picks since its inception five years ago. It went a perfect 4-0 on top-rated NFL picks in Week 1, including calling easy covers by the Ravens and Bills. The model enters Week 2 on an incredible 100-65 roll on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Titans vs. Jaguars. You can head to SportsLine to see its picks. Here are several NFL betting lines for Jaguars vs. Titans:

  • Titans vs. Jaguars spread: Titans -8.5
  • Titans vs. Jaguars over-under: 42 points
  • Titans vs. Jaguars money line: Tennessee -400, Jacksonville +320

What you need to know about the Titans

The Titans skirted past the Denver Broncos 16-14 on Monday. Ryan Tannehill passed for two TDs and 249 yards on 43 attempts. Derrick Henry has seven rushing TDs in his past three games vs. Jacksonville. A.J. Brown had four catches for 135 yards and a TD in the last meeting, but he's been ruled out (knee) for this week. Jonnu Smith is aiming for his third game in row at home with 60-plus receiving yards

The Titans have won five of the past six meetings between the teams. Mike Vrabel is 3-1 vs. Jacksonville. 

What you need to know about the Jaguars

Jacksonville took care of business in its home opener. The Jags were able to score a win over the Indianapolis Colts this past Sunday, 27-20. Gardner Minshew passed for three TDs and 173 yards on 20 attempts with a passer rating of 142.3. James Robinson led the team with 90 scrimmage yards (62 rush, 28 receiving) last week in his NFL debut, the fourth-most scrimmage yards by an undrafted rookie running back in Week 1 since 1970.

DJ Chark had five receiving TDs in seven road games last season. Josh Jones tied a career high with his team-high 12 tackles last week. Josh Allen has two sacks in two career games vs. Tennessee. 

How to make Titans vs. Jaguars picks

SportsLine's model has simulated Titans vs. Jaguars 10,000 times and the results are in. The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Jaguars vs. Titans? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Titans vs. Jaguars spread to jump on Sunday, all from the model that enters Week 2 of the NFL season on an incredible 100-65 roll.