The Minnesota Vikings and the Detroit Lions are set to square off in an NFC North matchup at 1 p.m. ET on Sunday at U.S. Bank Stadium. The Vikings are 1-3 overall and 1-1 at home, while Detroit is 0-4 overall and 0-2 on the road. Minnesota lost to Cleveland last Sunday, 14-7. Detroit fell to Chicago, 24-14. 

The Lions are one of two winless teams remaining in the NFL after four weeks. Minnesota is favored by 10 points in the latest Vikings vs. Lions odds from Caesars Sportsbook, and the over-under is set at 49.5. Before entering any Lions vs. Vikings picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Vikings vs. Lions. You can head to SportsLine to see its picks. Here are several NFL betting lines for Lions vs. Vikings:

  • Vikings vs. Lions spread: Vikings -10
  • Vikings vs. Lions over-under: 49.5 points
Featured Game | Minnesota Vikings vs. Detroit Lions

What you need to know about the Vikings

After scoring on their opening drive vs. the Browns, the Vikings did not score on their next 11 possessions. Kirk Cousins threw his first interception of the season and finished with 203 passing yards with one TD. He has three-plus TD passes in four of his last five games vs. the Lions. He has 26 TDs and nine interceptions in his last 10 home games. 

Dalvin Cook (ankle) rushed for just 34 yards on nine carries last week and is questionable for the game vs. Detroit. Justin Jefferson had nine catches for 133 yards in his last meeting with the Lions. Minnesota has won its last seven meetings with Detroit. 

What you need to know about the Lions

The Lions have 39 wins in 119 career matchups with the Vikings. Detroit has lost in 21 of his last 27 games at Minnesota. The Lions have not won in eight consecutive games overall. Detroit did not score in four trips into the red zone vs. Chicago in Week 4. 

D'Andre Swift has 167 scrimmage yards in two career games vs. Minnesota. Kalif Raymond had his first career two-TD game last week. T.J. Hockenson (knee) is questionable for Week 5. 

How to make Lions vs. Vikings picks

The model is leaning over on the total, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

Who wins Vikings vs. Lions? And which side of the spread has all the value? Visit SportsLine right now to see which side of the Vikings vs. Lions spread to jump on, all from the model that has crushed its NFL picks.