Gary Patterson and Les Miles are two of the biggest names in coaching, but they've only gone head-to-head once, back in 2013 when LSU beat TCU 37-27 at AT&T Stadium. However, the legendary head coaches are destined to become more familiar with each other now that Miles is the head coach at Kansas as the Jayhawks come to Amon G. Carter Stadium on Saturday to take on TCU. It's a noon ET kickoff and the Horned Frogs are favored by 15 points with the over-under at 48.5 in the latest TCU vs. Kansas odds. TCU enters the contest at 2-1 on the season, while Kansas is 2-2. But before you make any TCU vs. Kansas picks, be sure to see the Week 5 college football predictions from the proven computer model at SportsLine. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed it have seen massive returns. Over the past four years, the proprietary computer model has generated a stunning $5,310 profit for $100 bettors on its top-rated college football against the spread picks. The model enters Week 5 on a roll, going a blistering 42-18 on its top-rated picks. It also called Notre Dame (+16) covering against Georgia and Auburn (+4) covering against Texas A&M in two of the biggest games in Week 4. Anybody who has been following it is way up.

Now, it has simulated TCU vs. Kansas 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

It was a hard-fought contest, but the Horned Frogs had to settle for a 41-38 defeat against SMU last week. They were boosted by RB Darius Anderson, who rushed for 161 yards and two touchdowns on 19 carries. Anderson now has 430 yards from scrimmage and four touchdowns in three games this year and he'll be the focal point of the offense again on Saturday.

Kansas, meanwhile, looks like it has already made significant improvement in its first season under Miles. The Jayhawks went 3-9 in their final season under David Beaty, but already have a couple wins this season, including a 48-24 thumping of Boston College on national TV two weeks ago.

Kansas put up 567 yards of total offense in that game, out-gaining the Eagles by 120 yards. Both Pooka Williams and Khalil Herbert surpassed the 100-yard mark in that game with Williams rushing for 121 yards and a score and Herbert providing 187 yards and a touchdown. Andrew Parchment also had eight catches for 100 yards and two touchdowns, so Kansas feels like it has the skill position talent to attack a TCU defense that gave up 406 yards in a loss to SMU last week

So who wins TCU vs. Kansas? And which side of the spread is hitting in well over 50 percent of simulations? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.