For just the second time in history, two quarterbacks selected No. 1 overall will square off in the Super Bowl. Matthew Stafford went first to the Lions in 2009, while Joe Burrow was taken by Cincinnati in 2020. The two QBs had different journeys to reach the 2022 Super Bowl, but they've both been fixtures in Fantasy football lineups all season. Stafford finished third in the NFL in passing yards, Burrow was sixth, and each QB was among the top eight in positional Fantasy football rankings.

Which signal-caller should you favor in Super Bowl 56 on Sunday? Stafford has 11 more years of NFL experience, but Burrow has the edge in championship game experience, counting his work at LSU. Fantasy contests could be won or lost based on the quarterbacks' performances, so which path should you take in your Super Bowl Fantasy football rankings? Before locking in in your Fantasy football lineups for Super Bowl 56, be sure to check out the playoff Fantasy football rankings from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

In the championship round, the model was extremely high on 49ers wide receiver Deebo Samuel, ranking him as the top player at his position. The result: Samuel finished with 98 all-purpose yards and a touchdown in San Francisco's loss. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its 2022 Super Bowl Fantasy football rankings. Head to SportsLine now to see them.

Top 2022 Super Bowl Fantasy football picks 

One player the model is high on: Rams running back Cam Akers. The second year tailback made a miraculous comeback after suffering a torn Achilles before the season began.

Akers has 54 rushing attempts during the 2022 NFL playoffs after making his return from injury in Week 18. He's also contributed as a receiver, hauling in five catches on six targets for 62 yards, or a strong 12.4 yards per reception. Akers has now had two weeks to rest up for the 2022 Super Bowl and will be a central focus of the Rams' offense.

And a massive shocker: Bengals running back Joe Mixon, who finished the regular season ranked in the top five in carries (292), yards (1,205) and touchdowns (13), stumbles big-time and averages just 3.2 yards per carry against Los Angeles. 

Mixon is averaging just 3.7 yards per carry in the 2022 NFL playoffs and has had trouble finding the end zone in recent weeks. In fact, Mixon has scored just one touchdown in his last four games. In addition, Los Angeles' defense is giving up just 54.0 rushing yards per game during the postseason. With such a tough matchup on Sunday, Mixon is a player to consider leaving out of your 2022 Super Bowl Fantasy football lineups. 

How to set 2022 Super Bowl Fantasy football lineups

The model is also calling for an under-the-radar player to easily exceed his season averages. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising player could lead you to victory? Visit SportsLine now to get NFL playoff Fantasy football rankings for every position, plus see which player is going to easily exceed his season averages, all from the model that has out-performed experts big-time.