There are some tough Fantasy calls to make in Week 5 of the NFL season as injuries are piling up and offenses are scoring at an unheard of rate. Will Antonio Brown finally break out for week-winning numbers against a Falcons team that's given up 74 total points the last two games? Which receiver will Philip Rivers target the most against an Oakland defense that has struggled this season? Can the Texans protect Deshaun Watson after allowing 17 sacks through four weeks? The Week 5 Fantasy football rankings from SportsLine will help guide you through all these storylines and more as you decide who to start and who to sit in Fantasy football.  

When it comes to ranking players, their advanced computer model beat human experts in Fantasy football last season when there were big differences in ranking. And the model was closest to the hole overall, meaning it best pinpointed where every player would finish each week. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Last week, the model was high on Rams wide receiver Cooper Kupp. The result: Kupp exploded for 162 yards and two touchdowns against the Vikings, and anybody who had him in their lineup was well on their way to a Week 4 victory. 

Now the model, which simulates every game 10,000 times, has revealed its Fantasy Football rankings for Week 5 of the NFL season. 

One player the model loves this week in its Fantasy football rankings: Lions wide receiver Golden Tate, who is starting in less than 70 percent of CBS standard leagues. SportsLine's projections say he'll be a top-10 receiver this week, out-performing players like JuJu Smith-Schuster, Emmanuel Sanders, and Calvin Ridley.

Tate has been targeted at least eight times in every game this season and has at least 100 yards in half those outings, including in Week 4 against Dallas when he caught eight passes for 132 yards and two touchdowns. Look for him to push for similar numbers this week against a Green Bay defense that has already given up big numbers to receivers like Adam Thielen (12-131-1) and Stefon Diggs (9-128-2) this season.

And a massive shocker: Chiefs quarterback Patrick Mahomes stumbles big-time this week against the Jaguars and finishes well outside the top 10. He's a player to bench in Week 5. 

The Jaguars' defense has given up just four touchdown passes all season and is also allowing the fewest points per game at just 14. And Mahomes has yet to face a defense ranked in the top 15 in his young career. 

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top 10 of the Week 5 Fantasy Football rankings. This pick could be the difference between winning big and going home with nothing. 

So who should you sit and start this week? Visit SportsLine now to get Week 5 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that out-performed experts big time last season.