The New York Yankees continue their West Coast road trip when they open a three-game series against the Los Angeles Angels on Monday at Angel Stadium in Anaheim. The Yankees (78-50) are coming off a split of a four-game series at Oakland. They trail the Astros by 3½ games for the best record in the American League. Meanwhile the Angels (55-73) are riding high after sweeping the Blue Jays. New York is a -190 favorite (risk $190 to win $100) in the latest MLB odds from Caesars Sportsbook while Los Angeles is a +158 underdog. First pitch is set for 9:38 p.m. ET. 

The game is one of eight on the MLB schedule for Monday. Elsewhere in the majors, the Cardinals (-220) start a three game-series at Cincinnati, and the Padres and Giants (-130) renew their rivalry in San Francisco. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 309-266 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has locked in three confident MLB best bets for Monday. They all involve games at 6:40 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 13-1. You can only see the model's MLB picks at SportsLine

Top MLB picks today

The model, which ran 10,000 simulations on each of Monday's games, likes Arizona (+158) to beat Philadelphia. The Diamondbacks (59-67) have won three consecutive games, which is tied for the longest active winning streak in the majors, and four of their last five. Meanwhile the Phillies (72-56) were blanked by Pittsburgh in a 5-0 loss on Sunday.

Arizona enters the series hot at the plate. Over the last three games, the Diamondbacks are averaging 6.7 runs per game. Twelve of their 20 hits have been extra-base hits, including nine home runs. Catcher Daulton Varsho is 4-of-10 with a homer and a double over that stretch. See who else to back right here.

Featured Game | Arizona Diamondbacks vs. Philadelphia Phillies

How to make MLB picks and parlays for Monday

The model also locked in two other best bets for Monday, including a play on an even bigger underdog. You can see the model's MLB Monday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of almost 13-1? And what underdog does the model like on Monday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 309-266 run on top-rated MLB money-line picks since the start of 2021