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The New York Mets will try to exact revenge on the Houston Astros when the two teams open a two-game series on Tuesday at Citi Field. Last week the Mets (47-27), who have the best record in the National League, dropped both games of a two-game series to the Astros in Houston. The Astros (45-27) are coming off a split of a four-game series against the Yankees in the Bronx. Houston is a -125 favorite in the latest Astros vs. Mets odds from Caesars Sportsbook while New York is a +105 underdog.

First pitch is set for 7:10 p.m. ET from Queens, N.Y. The game is one of 16 on the MLB schedule for Tuesday. Elsewhere in the majors, the Braves take on the Phillies in Philadelphia and the Twins and Guardians play a doubleheader in Minneapolis. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Tuesday. They all involve games at 8:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 13-1. You can see the model's MLB picks for Tuesday only at SportsLine. 

Top MLB picks today

The model, which simulated each of the 16 games on Tuesday's schedule 10,000 times, is picking the Chicago White Sox (+110) to take out the Los Angeles Angels at 9:38 p.m. ET (see tickets at StubHub). The White Sox send out righty Johnny Cueto (1-4, 3.19), who has dominated Los Angeles in his career, going 4-0 with a 1.34 ERA. Meanwhile, the Angels counter with rookie Chase Silseth (1-2, 4.96 ERA), who is winless in his last three starts and couldn't get out of the second inning in his last outing.

In addition, Chicago's Andrew Vaughn is having a standout season. The 24-year-old designated hitter ranks 13th in the majors in batting average (.314). In the month of June, he has an overall slash line of .340/.393/.440.

Featured Game | Los Angeles Angels vs. Chicago White Sox

How to make Tuesday MLB parlays

The model also locked in three other best bets for Tuesday, including a play on an even bigger American League underdog. You can see the model's MLB Tuesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of almost 13-1? And what underdog does the model like on Tuesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 59-51 roll on top-rated MLB money-line picks through 12 weeks.