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The San Antonio Spurs and the Memphis Grizzlies are set to square off in a Southwest Division matchup at 8:30 p.m. ET on Wednesday at the AT&T Center. The Spurs are 31-44 overall and 14-23 at home, while Memphis is 53-23 overall and 25-13 on the road. The Grizzlies can clinch the No. 2 seed in the Western Conference playoffs with a win on Wednesday night. 

Memphis is favored by five points in the latest Spurs vs. Grizzlies odds from Caesars Sportsbook, while the over-under is set at 234. Before entering any Grizzlies vs. Spurs picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 24 of the 2021-22 NBA season on a stunning 83-51 roll on all top-rated NBA picks, returning over $2,600. Anyone following it has seen huge returns.

Now, the model has set its sights on Spurs vs. Grizzlies. You can head to SportsLine to see its picks. Here are several NBA betting lines for Spurs vs. Grizzlies:

  • Spurs vs. Grizzlies spread: Spurs +5
  • Spurs vs. Grizzlies over-under: 234 points

What you need to know about the Spurs

San Antonio brings a four-game winning streak into this matchup after picking up a 123-120 win over Houston on Monday. The Spurs also recorded wins over the Warriors, Trail Blazers and Pelicans during that road trip. They officially passed the Lakers in the race for the final spot in the Western Conference play-in tournament when Los Angeles lost on Tuesday night. 

The Spurs are one game back of New Orleans for the No. 9 seed with seven games remaining. Point guard Dejounte Murray leads San Antonio with 21.0 points, 9.3 assists and 8.3 rebounds per game. The Spurs have won five of their last six games against Western Conference opponents. 

What you need to know about the Grizzlies

Memphis has been red-hot over the last few weeks, winning nine of its last 10 games. The Grizzlies are currently riding a five-game winning streak that includes wins over the Nets, Bucks and Warriors. They have an opportunity to clinch the No. 2 seed in the Western Conference with a win on Wednesday night. 

Star guard Ja Morant remains sidelined due to a knee injury, but the Grizzlies have gone 18-2 without him this season. Shooting guard Desmond Bane continues to step up, averaging 18.2 points per game. The Grizzlies have won six straight games against San Antonio. 

How to make Grizzlies vs. Spurs picks

The model has simulated Spurs vs. Grizzlies 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Grizzlies vs. Spurs? And which side covers over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its NBA picks.