Kirk Cousins and the Minnesota Vikings (11-3) are set to host Daniel Jones and the New York Giants (8-5-1) in a key Week 16 NFC matchup at on Saturday at U.S. Bank Stadium. The Vikings are 7-1 at home, while New York is 4-2 on the road. The Giants are coming off a massive 20-12 NFC East win over the Washington Commanders, while the Vikings are fresh off completing the biggest comeback in NFL history in their 39-36 overtime win over the Indianapolis Colts. Minnesota erased a 33-0 deficit in the win.

Kickoff is at 1 p.m. ET. Minnesota is favored by 4 points in the latest Vikings vs. Giants odds from Caesars Sportsbook, and the over/under is set at 48.5. Before making any Giants vs. Vikings picks, you'll want to see the NFL predictions and betting advice from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Vikings vs. Giants and just locked in its picks and NFL Week 16 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Vikings vs. Giants:

  • Vikings vs. Giants spread: Vikings -4
  • Vikings vs. Giants over/under: 48.5 points
  • Vikings vs. Giants money line: Minnesota -210, New York +175
  • Vikings vs. Giants picks: See picks here
Featured Game | Minnesota Vikings vs. New York Giants

What you need to know about the Vikings

The Vikings have already locked up the NFC North and still have an outside chance at landing the top seed in the NFC playoff bracket. For that to happen, they would need to win out and hope the Philadelphia Eagles lose out. While the top seed is unlikely, the No. 2 seed is still very valuable and would give the Vikings at least two home playoff games.

The Vikings have arguably the best wide receiver in the NFL in third-year pro Justin Jefferson. The former LSU Tiger leads the league in receptions (111) and receiving yards (1,623), and has seven touchdown receptions.

What you need to know about the Giants

Meanwhile, New York picked up a 20-12 victory over the Washington Commanders on Sunday. New York can attribute much of its success to a strong defensive effort and a solid game from running back Saquon Barkley, who punched in one rushing touchdown.

The Giants enter this matchup ranked third worst in the NFL in rushing yards allowed per game (150.4), but the Vikings have a bottom five rushing attack averaging 95.4 yards per game on the ground. The reality of the situation here is that New York has more to play for in this game with a playoff spot on the line. New York currently holds the No. 6 seed in the NFC, and a win would go a long way in creating some separation in a tight race.

How to make Vikings vs. Giants picks

The model has simulated Vikings vs. Giants 10,000 times and the results are in. The model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins Giants vs. Vikings? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Vikings vs. Giants spread you need to jump on Saturday, all from the model that has crushed its NFL picks, and find out.