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There are multiple divisional matchups on Wild Card Weekend, including an AFC North rivalry between the Steelers and Browns on Sunday. Division rivalries in the NFL are often difficult to pick when deciding which team to back in your NFL bets. That's because the two teams are often extremely familiar with each other, which can lead to a surprising upset. The Steelers have won 10 straight meetings against Cleveland at Heinz Field, but can you trust them with your NFL picks after losing four of their last five games?

Pittsburgh is a six-point favorite at home according to the latest Wild Card Round NFL odds from William Hill Sportsbook. Will Pittsburgh pull off the home victory and advance to the next round of the NFL playoff bracket, or will Cleveland shock the world and win its first postseason game since 1994? All of the 2021 Wild Card Round NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best 2021 Wild Card Round NFL picks now

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 23-13 on top-rated NFL picks this season, returning well over $800. The model also enters the 2021 NFL Playoffs on an incredible 119-77 run on top-rated NFL picks that dates back to the 2017 season.

Additionally, the model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, it has examined the latest 2021 Wild Card Round NFL odds and NFL betting lines from William Hill, simulated every snap, and its predictions are in. Head to SportsLine now to see them all.

Top NFL predictions for the 2021 Wild Card Round

One of the top Wild Card Round NFL picks the model recommends: The Steelers (-6) cover against the Browns. Cleveland earned its spot in the NFL playoff bracket with a 24-22 victory over the visiting Steelers last week, who rested quarterback Ben Roethlisberger.

The Browns will be without coach Kevin Stefanski, Pro Bowl guard Joel Bitonio and wide receiver KhaDarel Hodge due to COVID-19. The Steelers crushed the Browns, 38-7, in Week 6 when both teams were at full strength, as Cleveland quarterback Baker Mayfield threw two interceptions, including a pick-six to Pittsburgh's Minkah Fitzpatrick.

SportsLine's model predicts that the Steelers cover the spread in almost 60 percent of simulations. The under (47.5) also hits almost 60 percent of the time.

Another one of the top Wild Card Weekend NFL predictions from the model: The Ravens (-3) cover against the Titans. The Ravens enter Sunday's showdown averaging 191.9 rushing yards per game this season, which ranks first in the NFL. Tennessee, meanwhile, is averaging 168.1 yards per game on the ground, the second-best mark in the league. 

The Titans are 5-2 in their last seven games, but their defense has begun to deteriorate over the last few weeks. In fact, Tennessee has given up at least 38 points in three of its last five games. Baltimore, meanwhile, has given up 14 or fewer points in its last three outings. In addition, the Ravens have been sensational on the road, winning 12 of their last 14 road games.

SportsLine's model projects that Baltimore's defense will hold the Titans to just 23 points on Saturday, resulting in the Ravens covering the spread in over 50 percent of simulations. The under (54.5) also has value because that hits over 60 percent of the time.

How to make 2021 Wild Card Round NFL picks

The model has also made the call on every other game on the NFL Wild Card Round schedule and identified a top Super Bowl contender that gets a huge scare. You can only get every pick for every game here.

What NFL picks can you make with confidence during the 2021 NFL Wild Card Round? And which contender gets a huge scare? Check out the latest NFL odds from William Hill below and then visit SportsLine to see which NFL teams are covering in more than 50 percent of simulations, all from the model that is up nearly $7,900 on its top-rated NFL picks

NFL odds, matchups for the 2021 NFL Wild Card Round

Saturday, Jan. 9

Indianapolis Colts vs. Buffalo Bills (-6.5, 51.5)

Los Angeles Rams vs. Seattle Seahawks (-3, 42)

Tampa Bay Buccaneers vs. Washington Football Team (+8, 44.5)

Sunday, Jan. 10 

Baltimore Ravens vs. Tennessee Titans (+3, 54.5)

Chicago Bears vs. New Orleans Saints (-10, 47)

Pittsburgh Steelers vs. Cleveland Browns (+6, 47.5)