patrick-mahomes-chiefs-usatsi.jpg
USATSI

San Francisco's hot streak came to an end last week, as the 49ers lost to Baltimore by two touchdowns on Christmas Day. The 49ers had rattled off a six-game winning streak prior to that loss, but they still control their own destiny to clinch the No. 1 seed in the NFC. Sunday afternoon presents a chance for the 49ers to get back on track, as they are 14-point favorites against Washington in the latest Week 17 NFL odds via SportsLine consensus. They are one of three double-digit favorites in the Week 17 NFL spreads, as the Bills and Eagles are both heavy favorites in their respective games.

Double-digit spreads can be difficult to evaluate at this time of the season, as several teams could be lacking motivation after being eliminated from playoff contention. Which teams should you include in your Week 17 NFL parlays? Before you make any Week 17 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 17. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 17 NFL picks at SportsLine.

Top Week 17 NFL picks

After simulating every game 10,000 times, the model is backing the Chiefs (-6.5) to cover against the Bengals in a 4:25 p.m. ET start on Sunday. Kansas City can clinch the AFC West title on Sunday following its loss to Las Vegas on Monday. Cincinnati's path to the playoffs became far less realistic following a blowout loss to Pittsburgh, with backup quarterback Jake Browning throwing three interceptions and getting sacked three times.

Star wide receiver Ja'Marr Chase missed that game due to a shoulder injury, and he could be held out again on Sunday afternoon. Chiefs running back Isiah Pacheco has scored four touchdowns in his last three games, racking up 110 yards and a score against Green Bay earlier this month. Kansas City has been the cream of the crop in the AFC, winning 13 of its last 16 games against AFC opponents, and the Chiefs are covering the spread in nearly 60% of the model's latest simulations. See which other NFL parlay picks to make here.

How to make Week 17 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including one favorite that covers with almost a touchdown to spare. You can only see the model's Week 17 NFL best bets and parlay at SportsLine

What are the model's top Week 17 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 17 NFL best bets from a model on a 178-129 run on top-rated picks, and find out.