The New England Patriots will try to avoid their first 0-2 start to a season since 2001 when they take on the Pittsburgh Steelers on Sunday. Last week, the Patriots (0-1) fell 20-7 to Miami. Meanwhile, the Steelers (1-0) shocked Cincinnati, 23-20. Sunday's matchup will be the first New England vs. Pittsburgh game since 1998 that will not feature Tom Brady or Ben Roethlisberger. New England is favored by 2.5 points in the latest NFL odds from Caesars Sportsbook, but which side should you back with your NFL bets? The game is one of 16 on a loaded Week 2 NFL schedule. Other key NFL matchups include the Bears facing their nemesis, Packers quarterback Aaron Rodgers, and the Bills and Titans colliding in one of two Monday Night Football games. Before you make any Week 2 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.  

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 2. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 2 NFL picks at SportsLine

Top Week 2 NFL picks

After simulating every game 10,000 times, the model is high on the Cleveland Browns to win and cover against the New York Jets. After beating Carolina in Week 1, Cleveland is 1-0 for the first time since the 2004 season. New York is 0-1 for the fourth straight season after a listless 24-9 loss to Baltimore.

The Browns face a Jets offense coming off an error-filled game. New York committed two turnovers and quarterback Joe Flacco was sacked three times and pressured 19 other times by the Ravens. The Jets did not score a touchdown until the final minute of the game. See which other NFL parlay picks to make here.

How to make Week 2 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model's NFL Week 2 best bets and parlay at SportsLine

What are the model's top Week 2 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 2 NFL best bets from a model on a 139-98 run on its top-rated picks, and find out.