Wilson is slated to be the 49ers' lead running back Thursday at Tennessee after Elijah Mitchell (knee) was ruled out for the contest.

Mitchell cleared the concussion protocol earlier this week, but his knee issue was bothersome enough to keep him off the practice field Tuesday and Wednesday and on the sideline for a third straight game. Wilson has taken on a majority share of the running back reps in the meantime, racking up 36 touches for 175 yards from scrimmage and one rushing TD. JaMycal Hasty is the only other RB on the active roster, but wide receiver Deebo Samuel and even fullback Kyle Juszczyk are likelier options to earn touches out of the backfield behind Wilson.

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