Division leaders take center stage in an interleague matchup on Friday evening in Major League Baseball. The Chicago White Sox visit the Milwaukee Brewers, with both teams playing inspired baseball. Freddy Peralta leads the way as the projected starting pitcher for Milwaukee. The White Sox will counter with talented hurler Lucas Giolito in this high-profile clash.

The MLB odds for Friday from William Hill Sportsbook list the Milwaukee Brewers as -125 favorites (risk $125 to win $100) against the Chicago White Sox. Other MLB lines of note include the Washington Nationals (-125) against the Baltimore Orioles and the New York Yankees as money-line favorites (-111) against the Boston Red Sox. Before making any MLB picks or predictions for Friday night, you need to see what the SportsLine Projection Model has to say.

This model, which simulates every pitch of every game 10,000 times, is 125-99 on top-rated MLB money-line picks through 16 weeks in the 2021 season, returning over $600. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. Anyone following it has seen huge returns.

Now, the model has crunched the numbers for the Friday MLB schedule and posted its best bets. Successfully parlaying these four MLB picks today will pay over 14-1. Head to SportsLine now to see the picks

Top MLB picks for Friday, July 23 

SportsLine's model has found value in the Toronto Blue Jays (+110) against the New York Mets on Friday. Part of that belief stems from the brilliance of Toronto's offense. The Blue Jays lead Major League Baseball in home runs (144), OPS (.783) and slugging percentage (.456), with top-three marks in hits (826), batting average (.264) and on-base percentage (.327). 

They will face a relatively difficult matchup in New York's Tylor Megill, but he will make only his sixth MLB start and the Blue Jays could pounce on that inexperience. In addition, New York's offense has been a mess this season, even as the team sustains success. 

The Mets are 14th in the National League in runs scored (367) and last in hits (688), doubles (121) and total bases (1,133). Given that New York will be asked to face a top-flight pitcher in Toronto's Hyun-Jin Ryu, the Blue Jays project to be in a strong position.

Featured Game | New York Mets vs. Toronto Blue Jays

How to make MLB predictions, parlays for Friday, July 23 

The model has locked in three other Friday MLB best bets, including one on an even bigger underdog. You can see its best bets only at SportsLine.

So which MLB picks should you make on Friday for a shot at a return of over 14-1? And which underdog do you need to be all over? Visit SportsLine now to see today's top MLB picks, all from the projection model that is off to a fast start in 2021, and find out.