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Two AL East contenders collide when the Boston Red Sox and Toronto Blue Jays begin a four-game series on Friday at Fenway Park in Boston. The Red Sox (38-25) sit in second place in the division, one game behind the Rays. The Blue Jays (31-29) are in fourth place in the division, 6.5 games behind Tampa Bay. The Red Sox are -121 money-line favorites in the latest Red Sox vs. Blue Jays odds from William Hill Sportsbook, while the Blue Jays are +110 underdogs. The over-under for total runs scored is 9.5. 

The game is one of 14 on Friday's MLB schedule. Other matchups include two Cy Young winners -- the Mets' Jacob deGrom and the Padres' Blake Snell -- squaring off at Citi Field and the rival Cubs and Cardinals opening a three-game series at Wrigley Field. Before making any MLB picks or predictions on those games or others, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 79-62 on top-rated MLB money-line picks through 10 weeks, returning well over $600. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Friday and posted its best bets for the evening games. Parlaying these four MLB picks would pay 16-1. Head to SportsLine to see the picks

Top MLB picks for Friday, June 11

The model likes the Mariners (+147) to beat the Indians (7:10 p.m. ET). The Mariners (31-33) are playing the eighth game of a 10-game road trip. They are 3-4 in the first seven games. Meanwhile, the Indians (32-27) are returning home after going 2-3 on a trip that took them through Baltimore and St. Louis.

On Friday, Seattle gets another crack at the Indians' Aaron Civale (8-2, 3.49 ERA). On May 14, the Mariners roughed up the Cleveland righty for five runs on seven hits in 6.2 innings in a 7-3 victory. In his last two starts, Civale has surrendered eight earned runs and 17 hits in 12 innings. In addition, the Mariners are 4-1 in their last five games against the Indians. 

How to make MLB predictions, parlays for Friday, June 11

The model has locked in three other MLB best bets, including one on a surprising underdog in the National League. You can see the best bets only at SportsLine.

So which MLB picks should you make on Friday for a shot at a big return of 16-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Friday's top MLB picks, all from the projection model off to a fast start in 2021.