An important series in each league and the finale of the Subway Series highlight the Tuesday night MLB schedule. The MLB-best Dodgers (84-37) host the Brewers (65-56) in a key National League matchup at 10:10 p.m. ET. Meanwhile, the Astros (78-45) have the American League's best record, but they also take on a second-place team, facing the AL Central's Twins (62-58) at 8:10 p.m. ET. In New York, the Mets (79-45) and Yankees (75-48) have the second-best marks in their respective leagues, and the AL East-leading Yankees look to complete the two-game sweep. They took a 4-2 win at home on Monday after the Mets, who sit atop the NL East, won both games of the teams' first series this season, at home last month.

First pitch of the Mets vs. Yankees matchup is set for 7:05 p.m. ET. The Yankees are -130 favorites in the latest Yankees vs. Mets odds from Caesars Sportsbook, and the Mets are +110 underdogs. The Dodgers (-155) and Astros (-320) also are favorites to win Tuesday. The full 16-game MLB schedule means wagering opportunities are endless, and you can really cash in if you combine your favorite picks into a parlay. Before you lock in any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 305-263 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Tuesday. They all involve games at 7:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 16-1. You can only see the model's MLB picks at SportsLine

Top MLB picks today

One pick the model loves as part of its Tuesday parlay is the Rangers vs. Rockies matchup (8:40 p.m. ET) to go Under 10.5 runs (-120). The Under is 6-1-1 in the past eight Texas games, and Colorado is 5-3-1 to the Under in its past nine. These teams played a two-game set at the start of the season, and they combined for 15 runs total in those two games. They didn't even go over 11 hits in the second, and this run total is set pretty high, even for this pitching matchup.

The Rockies won 4-1 in the most recent meeting, while in an April 11 matchup, they had a 3-2 lead entering the ninth but needed 10 innings to pull out a 6-4 victory. Dane Dunning (3-6, 4.06 ERA) is scheduled to start for the Rangers on Tuesday, against Colorado's German Marquez (6-10, 5.05). Neither has been great, but each has allowed three runs or fewer in seven of their past eight starts. Neither team has much to play for, as both are well under .500. See who else to back right here.

Featured Game | Colorado Rockies vs. Texas Rangers

How to make MLB picks and parlays for Tuesday

The model has locked in three other best bets for Tuesday, including another confident play on a run total that pays out at plus money, and they all can help you earn a huge payday if you parlay the picks. You can only see the model's MLB parlay picks and best bets for Tuesday night at SportsLine.

Which MLB picks should you target for Tuesday in a parlay offering a payout of almost 16-1? And which run total play at plus-money is a must-back? Visit SportsLine now to see the MLB best bets for Tuesday from the model that is 305-263 on top-rated MLB money-line picks since the start of the 2021 season.