MLB: Milwaukee Brewers at San Francisco Giants

Two division leaders collide when the Los Angeles Dodgers host the Minnesota Twins on Tuesday at Dodger Stadium in Los Angeles. The Dodgers (75-33) own the best record in baseball and a 16-game lead over the Padres in the NL West. Meanwhile, the Twins (57-51) hold a one-game lead over the Guardians and a two-game lead over the White Sox in the AL Central. Los Angeles is a -235 favorite in the latest Dodgers vs. Twins odds from Caesars Sportsbook, while Minnesota is a +192 underdog. First pitch is set for 10:10 p.m. ET. 

The game is one of 16 on the MLB schedule for Tuesday. Elsewhere in the majors, Shohei Ohtani takes the mound for the Angels against the A's and the White Sox and Royals play a doubleheader in Kansas City. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 299-254 on top-rated MLB money-line picks since the start of the 2021 season, returning more than $800 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has locked in three confident MLB best bets for Tuesday. They all involve games at 9:40 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 21-1. You can see the model's MLB picks only at SportsLine

Top MLB picks today

After simulating every game on Tuesday 10,000 times, the model is high on the Giants (+148) to beat the Padres. San Francisco (54-55) has won three straight games and took the first game of the series against San Diego, 1-0, on Monday. Meanwhile, the Padres (61-51) have lost five in a row, despite making a slew of high-profile additions at the trade deadline.

San Diego has suddenly gone cold at the plate. Over the last five games, the Padres are hitting a paltry .168 and have averaged 1.4 runs per game. That's a significant drop from their season averages (.239 batting average and 4.3 runs per game). See who else to back right here.

Featured Game | San Diego Padres vs. San Francisco Giants

How to make MLB picks and parlays for Tuesday

The model also locked in two other best bets for Tuesday, including a play on an even bigger American League underdog. You can see the model's MLB best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of nearly 21-1? And what underdog does the model like on Tuesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 299-254 run on top-rated MLB money-line picks since the start of 2021.