The St. Louis Cardinals would like to send Yadier Molina and Albert Pujols out on a high note as they open the 2022 MLB playoffs against the Philadelphia Phillies on Friday. It is Game 1 of the National League Wild Card Series, and Molina and Pujols are expected to retire following the season after lengthy careers. The Cardinals (93-69) are making their 16th playoff appearance since 2000, and are eyeing their first World Series since losing in six games to the Boston Red Sox in 2013. The Phillies (87-75), who have not made the playoffs since 2011, last made the World Series in 2009, falling in six games to the New York Yankees. Zack Wheeler (12-7, 2.82) gets the ball for Philadelphia, while Jose Quintana (6-7, 2.93) totes the rubber for St. Louis.

Friday's game from Busch Stadium in St. Louis is slated to begin at 2:07 p.m. ET. The Cardinals finished the regular season with the 10th-best team batting average in MLB at .252, while the Phillies were eighth with a .253 mark. Both teams are listed at -110 on the money line in the latest Phillies vs. Cardinals odds from Caesars Sportsbook, while the over-under for total runs scored is 6.5. Before making any Cardinals vs. Phillies picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the final week of the regular season on an 18-8 run on top-rated money-line MLB picks, returning almost $700 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Cardinals vs. Phillies and revealed its coveted picks and predictions. You can head to SportsLine to see all of the model's MLB picks. Here are several MLB odds and trends for Phillies vs. Cardinals:

  • Phillies vs. Cardinals money line: St. Louis -110, Philadelphia -110
  • Phillies vs. Cardinals over-under: 6.5 runs
  • Phillies vs. Cardinals run line: Cardinals -1.5 (+196)
  • PHI: The Phillies are 14-5 in their last 19 Friday games
  • STL: The Cardinals are 20-7 in their last 27 games following a loss
  • Phillies vs. Cardinals picks: See picks at SportsLine
Featured Game | St. Louis Cardinals vs. Philadelphia Phillies

Why you should back the Cardinals

St. Louis, which has won the last two meetings against the Phillies, has lots of pop in its lineup. One of the Cardinals' top hitters is third baseman Nolan Arenado, who is hitting .293 with 30 homers, 103 RBI and 73 runs scored. He has hits in five of his last seven game, including a 2-for-3 performance with a homer and two RBI versus the Los Angeles Dodgers on Sept. 24. In six games vs. Philadelphia this season, Arenado terrorized the Phillies, batting .455 with one double, one triple, three homers and six RBI. He has eight homers and 31 RBI in 56 career games against them.

Also powering the lineup is second baseman Brendan Donovan, who hit .281 on the year with five homers, 45 RBI and 64 runs scored. He enters the postseason on an eight-game hitting streak. In his last appearance, he went 2-for-5 with an RBI and two runs scored in a win over the Pittsburgh Pirates. He had seven games where he had three-plus hits, including a 4-for-5 performance against Pittsburgh on June 14.

Why you should back the Phillies

Philadelphia will send right-hander Wheeler to the mound who has won four of his last six decisions, and has 163 strikeouts and just 34 walks this season. In Wheeler's last appearance, an 8-1 win at Washington on Sunday, he allowed just two hits, while striking out seven in five innings. He has dominated St. Louis this season, going 2-0 against the Cardinals. In 14 innings of work, he has allowed nine hits, two walks and 10 strikeouts with zero runs crossing the plate.

Third baseman Alec Bohm has helped fuel the Phillies offense, batting .280 with 13 home runs, 72 RBI and 79 runs scored. He has feasted on Cardinals pitching this season. In six games, he batted .421 with a triple, two homers and three RBI. In 13 career games against them, Bohm is 13-for-43 (.302) with one double, one triple, two homers and seven RBI.

How to make Phillies vs. Cardinals picks

SportsLine's model is leaning Over on the total, projecting 8.3 combined runs, and it says one side of the money line has all the value. You can only get the MLB model's picks at SportsLine.

So who wins Cardinals vs. Phillies? And which side has all the value? Visit SportsLine now to find out which side of you need to jump on, all from the model that has crushed its MLB picks, and find out.