49ers vs. Seahawks odds, line: Monday Night Football picks, predictions from advanced model on 90-60 run

Two teams that have experienced plenty of success through the years meet on Monday Night Football when the Seattle Seahawks visit the San Francisco 49ers. The Seahawks (7-2) have made the playoffs 17 times, including last season, while the 49ers (8-0) are taking aim at a 27th postseason appearance all-time, but first since 2013. Kickoff from Levi's Stadium is slated for 8:15 p.m. ET. Since 2010, Seattle has won four division championships and played in two Super Bowls, winning it all six years ago. Nevertheless, the Niners are favored by six in the latest 49ers vs. Seahawks odds, while the over-under for total points scored is 47, up from an open of 44.5. You'll want to see the current NFL predictions from the SportsLine Projection Model before entering any Seahawks vs. 49ers picks of your own.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on its top-rated NFL picks since its inception four years ago. It has nailed its recent top-rated NFL picks, entering Week 10 of the 2019 NFL schedule on a strong 28-17 run that dates back to last season. It's also on an incredible 90-60 roll on top-rated NFL picks that dates back to the 2017 season, The model also ranked in the Top 10 on NFLPickWatch for the third year in a row on straight-up NFL picks and beat more than 96 percent of CBS Sports office pool players. Anyone who has followed it is way up and consistently beaten NFL spreads.

Now, the model has dialed in on 49ers vs. Seahawks. We can tell you it is leaning over, and it has a strong against the spread pick that cashes in well over 50 percent of simulations. That one is only available at SportsLine.

The model knows that San Francisco has already clinched its first .500 season since going 8-8 in 2014. A win would give the 49ers their first winning campaign since going 12-4 in 2013, the last of three straight double-digit win seasons. San Francisco is also 4-1 against the spread in its last five home games against a team like Seattle that has a winning road record.

Overall, the Niners have covered five of their eight games this season and their last two games at home. The Over has hit in the last two 49ers contests, which came against the Cardinals (43.5) and Panthers (40.5). In the latter game, Jimmy Garoppolo and company hit the over on their own, blasting Carolina 51-13.

But just because San Francisco is perfect on the season does not guarantee it will cover the 49ers vs. Seahawks spread on Monday Night Football.

That's because Seattle has dominated the 49ers, winning 10 of the last 11 games played between them, including four of the past five at San Francisco. The Seahawks lead the all-time series 25-16, including 1-0 in the postseason. Seattle has had plenty of success under coach Pete Carroll, going 105-62-1, including 9-6 in the playoffs.

Offensively, running back Chris Carson has been putting up game-changing numbers, carrying 175 times for 764 yards and three touchdowns. He has six runs of 20-plus yards and has rushed for more than 100 yards in four of Seattle's past six outings. Last week against Tampa Bay, Carson carried the rock 16 times for 105 yards (6.6 average). He's also rushed for 100-plus yards against the Browns, Rams and Cardinals.

So who wins Seahawks vs. Niners on Monday Night Football? And which side of the spread can you bank on in well over 50 percent of simulations? Visit SportsLine now to see which side of the Seahawks vs. 49ers spread to jump on Monday, all from the advanced model that is up almost $7,000 on its top-rated NFL picks, and find out.

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