The Green Bay Packers (6-1) will visit the Arizona Cardinals (7-0) in a showdown between conference foes on Thursday Night Football. Arizona has put the league on notice and is a serious threat coming out of the NFC, while Green Bay has ripped off a six-game win streak and has its eyes set on a seventh. Receivers Davante Adams and Allen Lazard are both out for Green Bay due to COVID-19 protocols, while receiver DeAndre Hopkins (hamstring) is active for Arizona.

Kickoff from State Farm Stadium in Glendale, Ariz. is set for 8:20 p.m. ET. Arizona is favored by 6.5 points in the latest Packers vs. Cardinals odds from Caesars Sportsbook, while the Over-Under is 50.5. Before locking in any Cardinals vs. Packers picks, make sure you check out the NFL predictions and betting advice from the SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up almost $7,700 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 8 of the 2021 season on an incredible 126-85 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Packers vs. Cardinals 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model's TNF picks. Now, here are several NFL odds and betting lines for Packers vs. Cardinals:

  • Packers vs. Cardinals spread: Cardinals -6.5
  • Packers vs. Cardinals over-under: 50.5 points 
  • Packers vs. Cardinals money line: Arizona -280, Green Bay +230 
  • ARI: Cardinals are 5-0 ATS in their last five games overall 
  • GB: Under is 4-0 in Packers' last four games overall 
Featured Game | Arizona Cardinals vs. Green Bay Packers

Why the Cardinals can cover

Even though DeAndre Hopkins hasn't had over 100 receiving yards in a game this year, he is always an option to score. Hopkins has scored in five of the seven games he's played in, and the three-time All-Pro is one of the best red zone threats in the league. Hopkins has reeled in all six of his touchdowns in the red zone, being Kyler Murray's go-to option in that area of the field.

Rookie receiver Rondale Moore is another target in this offense. The 2021 second-round pick gives Murray a weapon with elite speed and quickness. Moore has caught 26 passes for 303 yards and a score. The Purdue product also has nine carries for 60 yards. His best game of the season came against the Minnesota Vikings, when he caught seven passes for 114 yards and a score. The shifty receiver has flashed his versatility as a runner and deep-threat for Arizona.

Why the Packers can cover

The absence of star wide receiver Davante Adams (reserve-COVID) is a clear concern for Green Bay, but the Packers have found ways to win without the All-Pro receiver in the past. In fact, they have a 6-0 straight-up record in games without him over the past two years. That should give quarterback Aaron Rodgers and company plenty of confidence in this tough road matchup.

Rodgers can get creative in the passing game and isn't afraid to spread the ball around. Six other players outside of Adams have at least nine catches this season. Green Bay could also see the return of big-play receiver Marquez Valdes-Scantling, who has been out since Week 3 with a hamstring injury.

How to make Packers vs. Cardinals picks 

SportsLine's model is leaning under on the point total, projecting the teams to combine for 48 points. The model also says one side of the spread hits well over 50 percent of the time. You can only see the model's Cardinals vs. Packers picks at SportsLine. 

So who wins Cardinals vs. Packers on Thursday Night Football? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the Cardinals vs. Packers spread to jump on, all from the advanced model that is up almost $7,700 on its NFL picks, and find out.