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Humphries (knee) has been ruled out for the remainder of Sunday's game against the Eagles, Jose M. Romero of The Arizona Republic reports.

Humphries appeared to hurt his left knee and needed the help of trainers to get off the field, according to Josh Weinfuss of ESPN.com. His exit will leave a void at left tackle, which Kelvin Beachum will step in and fill for the remainder of Week 17.

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