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Four Chicago Cubs pitchers combined for a no-hitter at the Los Angeles Dodgers on June 24, the record-tying seventh no-hitter overall of the 2021 MLB season. That victory improved the Cubs to 42-33. They haven't won since, dropping 11 in a row and falling to fourth in the NL Central Division. The odds aren't good that Chicago wins Wednesday, either, as it faces Philadelphia Phillies All-Star ace and Cy Young candidate Zack Wheeler. It's an 8:05 p.m. ET first pitch from Wrigley Field in the series finale. Chicago goes with journeyman Alec Mills.

The Cubs' 11-game losing streak is the team's longest since May 2012. The Phillies have crushed the Cubs in the first two games of this series, 13-3 and 15-10. It's the first time since 2000 the Cubs have given up 13 or more runs in consecutive games. They have allowed at least 10 runs four times in this 11-game skid. The latest MLB odds for Wednesday from William Hill Sportsbook list Philadelphia at -135 (risk $135 to win $100) on the money line in the latest Phillies vs. Cubs odds, with Chicago at +125.

Other MLB lines of note include the Houston Astros -140 at home against the Oakland A's; the Washington Nationals at -125 against the San Diego Padres; and the Seattle Mariners as potentially great value as +115 home underdogs vs. the New York Yankees. Before making any MLB picks for Wednesday night, you need to see what the SportsLine Projection Model has to say.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a sizzling start in 2021, going 113-87 on top-rated MLB money-line picks through 14 weeks, returning almost $900. Anyone following it has seen huge rewards.

Now, the model has crunched the numbers for the Wednesday MLB schedule and posted its best bets. Successfully parlaying these four MLB picks today will pay nearly 12-1. Head to SportsLine now to see the picks

Top MLB picks for Wednesday, July 7

One of the model's top MLB picks for Wednesday: The Phillies (-135) defeat the Cubs. Bryce Harper is red-hot for the Phillies right now. In Tuesday's 15-10 win at the Cubs, he homered for the seventh time in 13 games, tied a career high with five hits and knocked in a season-high four runs. Harper amazingly had hit 14 consecutive solo homers to open the 2021 season before a three-run shot on Tuesday. Andrew McCutchen had a grand slam and the Phillies scored double-digit runs in consecutive games for the first time since June 22-23, 2015.

Philadelphia shouldn't need close to double-digit runs to win Wednesday behind Wheeler, who is having the best season of his seven-year career with a 6-4 record and 2.05 ERA that is third in the National League. His 139 strikeouts are first -- ahead of NL Cy Young favorite Jacob deGrom, Wheeler's former teammate on the Mets. The Phillies are also 7-2 in their past nine vs. NL Central teams, while Chicago is 7-19 in its past 26 as an underdog. 

Featured Game | Chicago Cubs vs. Philadelphia Phillies

How to make MLB predictions, parlays for Wednesday, July 7

The model has locked in three other Wednesday MLB best bets, including a play on a surprising underdog. You can see its best bets only at SportsLine.

So which MLB picks should you make on Wednesday for a shot at a return of almost 12-1? And which underdog do you need to be all over? Visit SportsLine now to see Wednesday's MLB picks, all from the projection model that is off to a fast start in 2021, and find out.