Having a strong grasp on the Week 12 Fantasy football projections will help you set the best Fantasy football lineups possible. Four quarterbacks are coming off the bench this week, as Sam Darnold (Panthers), Mike White (Jets), Bryce Perkins (Rams), and Kyle Allen (Texans) will make their first starts of the year. Their promotions could have an impact on the Week 12 Fantasy football rankings for respective receivers like D.J. Moore, Garrett Wilson, Van Jefferson, and Brandin Cooks. Which players' arrows are pointing up and should find a way into your Week 12 Fantasy football lineups? Before setting your Fantasy football lineups, be sure to check out the Week 12 Fantasy football rankings from SportsLine's proven computer model.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Last week, the model was extremely high on Cowboys running back Tony Pollard, saying he'd finish as a top-10 player at his position. The result: Pollard rushed 15 times for 80 yards and caught all six of his targets for 109 yards and two touchdowns in Sunday's 40-3 win over the Vikings. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 12 of the 2022 NFL season. Head to SportsLine now to see them.

Top Week 12 Fantasy football picks  

One player the model is high on this week: Cardinals running back James Conner. After a rough start to the year from the two-time Pro Bowler, Conner has come on strong. He's found the end zone three times over his last two games after doing so just once over the first nine weeks. While his yardage totals won't jump off the page, he's gone over 50 scrimmage yards in all eight games this season.

The breakout game that Conner's Fantasy owners have been hoping for all season may finally come on Sunday against the Chargers. L.A. has allowed the third-most Fantasy points to opposing running backs and ranks dead last by allowing 5.5 yards per carry. The team has given up at least 200 rushing yards in three of its last six games and over 150 yards in two others. Conner is a top-15 running back option in the Week 12 Fantasy football rankings, as the model projects him to outproduce players like Alvin Kamara and Miles SandersSee who else to target here.

And a massive shocker: Texans wide receiver Brandin Cooks, who has had six 1,000-yard seasons in the last seven years, stumbles big-time and doesn't even crack the top 50 at his position. Cooks has been targeted at least six times in every game this season and a total of 66 times in nine games, which is the volume that typically leads to a player being a week-in, week-out starter in Fantasy football lineups.

However, Cooks has only managed 39 catches for 461 yards and a touchdown, and his value appears to be tapering off after nearly a decade of being a Fantasy-relevant player. He hasn't had a single 100-yard game this season and is averaging just over 10 points per game in PPR formats. Even in a plus matchup against Miami's 22nd-ranked pass defense, the target quality simply isn't there and he's a player who should be riding your bench unless you're hamstrung at wide receiver. See who else to fade here.

How to set Week 12 Fantasy football rankings

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top 10 of its Week 12 Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 12 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has outperformed experts big-time.