The Rays' Tyler Glasnow returns from Tommy John surgery to make his first start since June 14, 2021, when he takes the mound for Tampa Bay (85-69) against the Cleveland Guardians (86-68) on Wednesday. The 6-foot-8 righty was the team's Opening Day starter last year and went 5-2 with a 2.66 ERA in 14 starts before his injury. On Wednesday, he faces the Guardians' Triston McKenzie. Cleveland is a -130 favorite in the latest Guardians vs. Rays odds from Caesars Sportsbook, while Tampa Bay is a +110 underdog. The over/under for runs scored is 6.5.

First pitch is set for 6:10 p.m. ET at Progressive Field in Cleveland. The game is one of 15 on the MLB schedule for Wednesday. Elsewhere in the majors, Yankees slugger Aaron Judge takes another shot at tying the American League single-season home run record, against the Blue Jays, and the Dodgers and Padres collide in San Diego. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it enters the penultimate week of the regular season on a 14-3 run on top-rated money-line picks, returning almost $900 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games at 7:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 24-1. You can only see the model's MLB picks at SportsLine

Top MLB picks today

The model, which ran 10,000 simulations on each of Wednesday's games, likes National League Central champion St. Louis (+135) to knock off Milwaukee. The Cardinals (90-65) have won three of the last four meetings against the Brewers and 10 of the 18 matchups overall this season. Milwaukee (82-72) has lost four of its last five home games, including Tuesday's against St. Louis.

In addition, the Brewers have struggled this season against lefties. When facing southpaws this season, Milwaukee ranks 29th out of 30 MLB teams in batting average (.218) and 24th in OPS (.665). On Wednesday, the Brewers face lefty Jose Quintana, and the Cardinals are 9-1 in games he has started for them since he was acquired at the trade deadline. See who else to back right here.

Featured Game | Milwaukee Brewers vs. St. Louis Cardinals

How to make MLB picks and parlays for Wednesday

The model also locked in three other best bets for Wednesday, including plays on two even bigger underdogs. You can see the model's MLB Wednesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of more than 24-1? And what underdogs does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 14-3 run on top-rated money-line picks.