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After an enjoyable quadruple-header of MLB Wild Card Series action on Friday, the same teams will take the field on Saturday as the 2022 MLB playoffs roll on. The Toronto Blue Jays fell to the Seattle Mariners by a 4-0 margin in Game 1, struggling to solve Luis Castillo along the way. Toronto aims to bounce back in a win-or-go-home scenario at home on Saturday behind the arm of Kevin Gausman. Seattle counters with Robbie Ray, and the Mariners can close out the series with a win. Toronto is a -160 favorite (risk $160 to win 100) in the latest MLB odds from Caesars Sportsbook, while Seattle is a +135 underdog. The over/under for runs scored is 7.5. First pitch is at 4:07 p.m. ET in Toronto. 

Elsewhere Saturday on the 2022 MLB playoff schedule, the Tampa Bay Rays face the Cleveland Guardians (-115), the New York Mets (-190) host the San Diego Padres, and the Philadelphia Phillies (-125) take on the St. Louis Cardinals. Each series is a best-of-three, with the winners advancing to the divisional round. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the final week of the regular season on an 18-8 run on top-rated money-line MLB picks, returning almost $700 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Saturday. If you successfully parlay the picks, you'd be looking at a payout of around 15-1. You can only see the model's MLB picks at SportsLine

Top MLB playoff picks for Saturday

The model, which ran 10,000 simulations on each of Saturday's Wild Card Series matchups, sees value on the Blue Jays (-160) to defeat the Mariners. Some of the optimism stems from Toronto's balanced and potent offense. The Blue Jays sat atop the American League in several offensive categories this season, including OPS, total bases, on-base percentage, slugging percentage, hits and batting average. Toronto was also near the top of the league in home runs, runs scored, and doubles, with good plate discipline in taking more walks and giving away fewer strikeouts than an average AL team. 

The Blue Jays are also deploying a high-end starting pitcher in Gausman, who led the American League in FIP and strikeout-to-walk ratio in 2022. He has a 3.07 combined ERA over the last two seasons, and Gausman has a solid projected edge over Ray. See who else to back right here.

How to make MLB picks and parlays for Saturday

The model also locked in three other best bets for Saturday, and they include a pair of underdog plays. You can see the model's MLB best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of around 15-1? And which underdogs should you target? Visit SportsLine now to see the MLB best bets from an advanced model that is on an 18-8 run on top-rated money-line picks.