The Chicago White Sox and Detroit Tigers both will be looking to set the tone on Friday when they open their MLB seasons with a matchup at Detroit's Comerica Park. The White Sox are the reigning AL Central champions, but the Tigers feel like they should contend after a long rebuilding process. Detroit added several new pieces to their young nucleus after following up an 8-19 April by going 69-66 the rest of the way last season. The White Sox will be trying to win consecutive division titles for the first time in franchise history after they went 93-69 and lost to the Astros in the AL Division Series last fall. Chicago right-hander Lucas Giolito is set to start in place of the injured Lance Lynn, while Detroit is expected to go with lefty Eduardo Rodriguez. Tim Anderson (suspension) and Yoan Moncada (oblique) will miss this one for the White Sox. 

First pitch is scheduled for 1:10 p.m. ET. Caesars Sportsbook lists Chicago as a -140 favorite (risk $140 to win $100) on the money line in its latest White Sox vs. Tigers odds, and the over-under for total runs scored is 7.5. Before making any Tigers vs. White Sox picks, you need to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB money-line picks in 2021, returning over $700 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in on Tigers vs. White Sox, and just revealed its MLB picks and predictions. You can visit SportsLine now to see the model's picks. Here are the MLB odds and trends for White Sox vs. Tigers:

  • White Sox vs. Tigers money line: Chicago -140, Detroit +120
  • White Sox vs. Tigers over-under: 7.5 runs 
  • White Sox vs. Tigers run line: Chicago -1.5 (+125)
  • CWS: Jose Abreu has 40 extra-base hits in 65 games at Comerica Park 
  • DET: Javier Baez has 11 extra-base hits in 22 games against the White Sox
Featured Game | Detroit Tigers vs. Chicago White Sox

Why you should back the White Sox 

Chicago is 6-0 in Giolito's last six starts as a favorite, including 4-0 on the road. It will want to assert itself early and should be able to take advantage of a team with a lot of young players and new pieces. Giolito has started the past two Opening Days, and he left last year's game against the Angels with a 3-2 lead after allowing two runs on two hits and striking out eight. L.A. won it with two runs in the eighth. Giolito had a 3.53 ERA and 1.10 WHIP last season.

The White Sox are 37-16 in the last 53 meetings, and they have not had any trouble scoring runs. They were sixth in MLB in runs per game last season at 4.9 and had a plus-147 run differential, also sixth. Abreu and Yasmani Grandal provide most of the pop, with Abreu hitting 31 homers and Grandal putting up 23 despite missing more than a month. Young outfielders Luis Robert and Eloy Jimenez were both impressive this spring, driving in a combined 22 runs. Chicago pitchers averaged 10.2 strikeouts per game last season, best in MLB. 

Why you should back the Tigers

Detroit is ready to make some noise in the Central this season and will be looking to make a statement at home. Rodriguez went 64-49 with a 4.16 ERA and 1.31 WHIP in six seasons with the Red Sox. He is 2-0 with a 3.60 ERA in five starts against Chicago, striking out 34 in 31 innings. Giolito is 5-5 with a 4.57 ERA in 14 starts against Detroit. Rodriguez averages 149 strikeouts and 49 walks per season. The Tigers are 4-1 in the last five meetings in Detroit.    

The Tigers bulked up in a big way in the offseason, adding shortstop Javier Báez, who hit 31 home runs and drove in 117 runs with the Cubs and Mets last season. Then they made a trade with the Rays earlier this week for Austin Meadows, who had 106 RBI last season. Two-time Gold Glove catcher Tucker Barnhart also came over from the Reds. Friday also will mark the anticipated debut of first baseman Spencer Torkelson. The 2020 first overall draft pick hit .280 with a .440 slugging percentage in the spring after hitting 30 homers in the minors last year.

How to make White Sox vs. Tigers picks

SportsLine's model is leaning Over on the run total, as the simulation suggests the teams will combine for 10 runs. It also says one side of the money line has all the value. You can only get the model's Tigers vs. White Sox pick at SportsLine

So who wins Tigers vs. White Sox on Friday? And which side of the money line has all the value? Visit SportsLine now to see which side to jump on for White Sox vs. Tigers, all from the advanced model that is 209-178 on its top-rated MLB picks last season, and find out.