After Week 12 saw four quarterbacks make their first starts of the season, only one new signal-caller is expected to be under center in Week 13. Deshaun Watson of the Browns was typically near the top of Fantasy football rankings while in Houston, but it's been nearly two years since he took a meaningful snap. Should you plug him right back into Week 13 Fantasy football lineups against his former Texans squad that's among the most friendly to opposing QBs? There are pros and cons to utilizing Watson, making him one of the more complicated Week 13 Fantasy football start-sit decisions. Before setting your Week 13 Fantasy football lineups, be sure to check out the Week 13 Fantasy football rankings from SportsLine's proven computer model.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home emptyhanded.

Last week, the model was extremely high on Raiders running back Josh Jacobs, saying he'd finish as a top-five player at his position. The result: Jacobs ran 33 times for 229 yards and two touchdowns while also catching six passes for 74 yards. Anybody who had him in their lineup was well on their way to a huge week.  

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 13 of the 2022 NFL season. Head to SportsLine now to see them.

Top Week 13 Fantasy football picks  

One player the model is high on this week: Steelers wide receiver George Pickens. The second-round pick has been one of the few bright spots in Pittsburgh's sluggish offense and ranks third among rookies in receiving yards (510) despite being the 11th wideout drafted. He's also maintained a high floor and has either scored or produced 83-plus yards in six of his last eight games.

With the Falcons hosting Pittsburgh on Sunday, Pickens has a better chance of reaching his ceiling than floor. Atlanta has the No. 28 passing defense and has allowed the third-most Fantasy points to opposing wide receivers. The Week 13 Fantasy football projections have Pickens producing as a top-12 receiver on Sunday, giving him WR1 value in most-sized leagues. Pickens is also expected to outperform bigger names at the position including Mike Evans and DK MetcalfSee who else to target here.

And a massive shocker: Dolphins running back Jeff Wilson Jr., who has produced 267 scrimmage yards and three touchdowns in three weeks with Miami, stumbles big-time and doesn't even crack the top 35 at his position. The longtime San Francisco backup was a Fantasy football waiver wire star early in the season when 49ers running back Elijah Mitchell went down with a knee injury, but the acquisition of Christian McCaffrey briefly turned Wilson back into a bench or drop candidate.

However, Dolphins head coach Mike McDaniel acquired Wilson at the trade deadline, and Wilson's familiarity with McDaniel's offense allowed him to transition into the lineup. Wilson averaged only 3.0 yards per carry last week while through a lower leg injury that he suffered early in the game. Now, Raheem Mostert is expected to return to the lineup in Week 13 which could cut into Wilson's workload. See who else to fade here.

How to set Week 13 Fantasy football rankings

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top two of its Week 13 Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 13 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top two, all from the model that has outperformed experts big-time.