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The red-hot Boston Red Sox can extend their winning streak to a season's-best eight games on Monday when they take on the rival Toronto Blue Jays in the first game of a three-game set at the Rogers Centre in Toronto. For the second time this month, the Red Sox (42-31) are on a seven-game winning streak. They haven't won eight in a row since June 25-July 2 of last season. Meanwhile, the Blue Jays (40-32) have lost seven of their last 10 games. 

Toronto is a -185 favorite in the latest Blue Jays vs. Red Sox odds from Caesars Sportsbook while Boston is a +165 underdog. First pitch is set for 7:07 p.m. ET, and the game is one of nine on the MLB schedule for Monday. Elsewhere in the majors, White Sox starter Lucas Giolito (4-4, 5.40 ERA) looks to get back on track against the Angels, while the Guardians look to end the majors' longest current losing streak (four games) against the Twins. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Monday. They all involve games at 7:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 12-1. You can see the model's MLB picks for Monday only at SportsLine. 

Top MLB picks today

The model, which simulated each of the nine games on Monday's schedule 10,000 times, is taking St. Louis (-130) to beat Miami at 7:45 p.m. ET (see tickets at StubHub). With Sunday's loss to the Cubs, the Cardinals (41-34) have dropped to second in the NL Central. The Marlins (33-38) are coming off a series in which they lost two of three games to the NL East-leading Mets.

Rookie Brendan Donovan has been swinging a hot bat for St. Louis. In the month of June, the 25-year-old outfielder is hitting .337 with an on-base percentage of .427. He has 32 hits this month and is the first Cardinals rookie with 32 hits in June since Albert Pujols had the same number in June 2001. On Sunday, Donovan went 2-for-4 with a solo home run, a triple, a walk and two runs scored against the Cubs.

Featured Game | St. Louis Cardinals vs. Miami Marlins

How to make Monday MLB parlays

The model also locked in three other best bets for Monday, including a play on an American League underdog. You can see the model's MLB Monday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of more than 12-1? And what underdog does the model like on Monday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 59-51 roll on top-rated MLB money-line picks through 12 weeks.