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The Denver Broncos and Los Angeles Chargers wrap up the NFL Week 6 schedule with an AFC West rivalry game on Monday Night Football. Kickoff is at 8:15 p.m. ET. Russell Wilson and the Broncos are looking to rebound from their ugly 12-9 overtime loss to the Indianapolis Colts on Week 5 Thursday Night Football, while Justin Herbert and the Chargers are hoping to build off their 30-28 win over the Browns and extend their winning streak to three games. Both sides have been hit hard by injuries, but still have enough playmakers on both sides of the ball to make this matchup interesting. Should you target the Denver duo of Wilson and Courtland Sutton or the Chargers' combo of Herbert and Mike Williams in your NFL DFS lineups and NFL DFS stacks? Or does it make sense to build your MNF Showdown NFL DFS strategy around a star running back, wide receiver, tight end or defense? Jerry Jeudy, Melvin Gordon, Greg Dulcich, Austin Ekeler, and Gerald Everett all project to be impact classic and showdown NFL DFS picks for Monday Night Football. Keenan Allen (hamstring) has been ruled out for Los Angeles.

Before making any NFL DFS picks for Chargers vs. Broncos on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.

Kaylor has been spot-on all season, hitting on epic NFL DFS picks like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3), Amari Cooper (7-101-1), Nick Chubb (23-113-1), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1), Cooper Kupp (14-122), Travis Kelce (7-25-4), and Davante Adams (3-124-2).

Now, Kaylor has turned his attention to Broncos vs. Chargers on Monday Night Football Week 6 and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Chargers vs. Broncos on MNF

Part of Kaylor's optimal DFS strategy for Monday Night Football is rostering Chargers running back Austin Ekeler. In his last two games, the 27-year-old all-purpose back has 39 total touches, and produced 308 total yards and 5 touchdowns. With Pro Bowl wide receiver Keenan Allen likely to miss this matchup, Kaylor is expecting another heavy workload for Ekeler on MNF. If that happens, the Eaton, Colo. native could put on a show against his hometown team.

"Ekeler is coming off a monster game against the Browns in Week 5, and matchups against the Broncos have always been personal for the Colorado native. Denver has been a solid defensive team in 2022, but they have struggled to contain Ekeler in the past, and they allowed Raiders RB Josh Jacobs to go off in Week 4. I'm expecting a heavy workload for Ekeler on Monday night, especially with Keenan Allen likely out. I could easily see this ending up as a 20-touch night for Ekeler against the Broncos," Kaylor told SportsLine. You can see the rest of Kaylor's NFL DFS picks here.

How to build NFL DFS lineups for Broncos vs. Chargers on MNF

Kaylor is also targeting another undervalued value who could explode for huge numbers for Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor's MNF DFS picks, at SportsLine

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Monday Night Football? And which under-the-radar DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament in 2022, and find out.