Whether you're playing with friends, family or coworkers, making NFL office pool picks can be a challenge. The Week 1 NFL schedule is loaded with games between playoff teams from last season and NFL matchups expecting to be tightly-contested. Seahawks vs. Colts combines both elements, with the two teams coming off postseason appearances and Seattle favored by just 2.5 in the Week 1 NFL odds from Caesars Sportsbook. Where should you go with your NFL confidence pool picks?

That's just one of five games between playoff teams and one of eight with a spread of three points or fewer, so making your Week 1 NFL pool picks could be a challenge. Getting off to a strong start with your NFL confidence picks is always critical, so having a little help as you make your Week 1 NFL picks could go a long way. Before you make your NFL predictions, you need to see the Week 1 NFL football pool picks from SportsLine's proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 1 2021 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Go to SportsLine to see them.

Top Week 1 NFL office pool predictions

One of the top Week 1 NFL pick'em predictions from the model: San Francisco cruises past Detroit in a Week 1 matchup. The 49ers rode an exciting running game and a loaded defense to Super Bowl 54, but saw both elements of their game plan attacked a season ago by injury.

Raheem Mostert, Tevin Coleman and JaMycal Hasty all spent time on injured reserve to decimate the running back room, while San Francisco's pass defense was thwarted by serious injuries to Nick Bosa, Dee Ford and Jaquiski Tartt. Now, the 49ers will welcome back those three defensive stars, while Trey Sermon and Elijah Mitchell will provide needed depth at tailback.

Against a Lions defense that ranked 28th in rushing yards allowed and allowed a staggering 27 rushing touchdowns, expect the 49ers to get back to what made them strong in 2019. The model predicts that the 49ers rush for well over 150 yards en route to winning in over 70 percent of simulations and covering well over 50 percent of the time.

How to make Week 1 NFL office pool picks

The model also made the call on every other Week 1 game and has strong picks for potentially close matchups like Seahawks vs. Colts and Chiefs vs. Browns. It's also calling for a Super Bowl contender to go down hard. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 1 NFL game? And which Super Bowl favorite goes down hard? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks four of the last five years and went an outstanding 120-78 last season.