Quarterbacks will be a major storyline on Sunday when Week 10 of the NFL schedule resumes. While Aaron Rodgers of the Packers and Russell Wilson of the Seahawks will return to the lineup and face off at Lambeau Field, the Steelers' Ben Roethlisberger will miss Sunday's game against the Lions after being placed on the reserve/COVID-19 list. In addition, multiple reports say the Cardinals are pessimistic about whether Kyler Murray (ankle) will be able to play against the Panthers. Green Bay is a 3.5-point favorite in the latest NFL odds from Caesars Sportsbook, but which teams should you back with your NFL bets and NFL parlays?

Other key NFL matchups include Bill Belichick squaring off against his former team, the Browns, and receiver Odell Beckham Jr. potentially making his Rams debut on Monday Night Football against the 49ers. Before making any Week 10 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 10. If you successfully parlay its picks, you'd be looking at a massive payout of 25-1. You can only see the model's Week 10 NFL picks at SportsLine

Top Week 10 NFL picks

After simulating every game 10,000 times, the model is high on the Broncos to cover as 2.5-point favorites at home against the Eagles. Denver (5-4) sits just a half-game behind the Chargers and Raiders (both 5-3) in the crowded AFC West. Philadelphia (3-6) is in a dogfight with the Giants (3-6) and Washington (2-6) for second place in the NFC East, far behind the division-leading Cowboys (6-2).

Denver quarterback Teddy Bridgewater and the Broncos have a strong matchup against the Eagles' pass defense. Bridgewater is completing 70.2 percent of his passes, the best of his career. On Sunday, he faces a Philadelphia pass defense that has allowed five teams this season to complete 80 percent or more of its passes. Since passing stats became available in 1950, the Eagles have allowed just 14 other opponents 80 percent passing days.

How to make Week 10 NFL parlays

The model also jumped on four other matchups where it says the line is way off, including a divisional battle and a game between two teams fighting for their playoff lives. You can only see the model's NFL Week 10 best bets and parlay at SportsLine

What are the model's top Week 10 NFL picks? And which other matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 10 NFL best bets from a model on a 128-88 run on its top-rated picks, and find out.