Getty Images

One of the marquee matchups on the Week 4 college football schedule features Bo Nix and the Oregon Ducks hosting Shedeur Sanders and the Colorado Buffaloes. Nix has already thrown eight touchdown passes this season, helping the Ducks average 58 points per game. Meanwhile, the Buffaloes remained undefeated after a thrilling comeback victory over rival Colorado State. However, Colorado has struggled mightily against Oregon over the years, losing nine of their last 10 games against the Ducks.

The latest Week 4 college football odds from the SportsLine consensus list Oregon as 21-point favorites at home in that 330 p.m. ET kick. Elsewhere in college football, Alabama is a 7-point favorite at home against Ole Miss (3:30 p.m. ET, CBS) and Notre Dame is a 3.5-point underdog against Ohio State (7:30 p.m. ET). Before locking in any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest college football odds for Week 4 and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 4

One of the college football picks the model is recommending for Saturday: Baylor (+17) easily stays within the spread against No. 3 Texas in a 7:30 p.m. ET kickoff at McLane Stadium. Texas has won six of its last eight games against Baylor, but the Bears have each of their last two home games against the Longhorns.

In addition, Baylor seems to thrive in the underdog role. In fact, the Bears are 8-2-1 against the spread in their last 11 games when playing as the underdog. The model projects Baylor to put together a strong enough showing at home against Texas to keep the score close as the Bears cover the three-score spread in well over 60% of simulations.

Another prediction: Arkansas (+17.5) plays a competitive road game at No. 12 LSU on Saturday at 7 p.m. ET. Arkansas can take a lot of positives away from its disappointing loss to BYU at home last week. The Razorbacks had two receivers finish with over 75 yards, including Andrew Armstrong, who hauled in nine receptions for 98 yards.

Quarterback KJ Jefferson completed 24 of 35 pass attempts for 247 yards, one touchdown and one interception. Jefferson leads an Arkansas offense that is scoring 38.3 points per game this season. The senior signal caller is also an effective runner, which bodes well against an LSU defense that's giving up 130.7 rushing yards per game, which ranks 12th in the SEC. Arkansas, meanwhile, is giving up just 55.7 rushing yards per game on defense, which ranks first in the conference. That's a big reason why the model has Arkansas covering the spread in more than 60% of simulations on Saturday. See which other teams the model likes here.

How to make college football picks for Week 4

The model has also made the call on who wins and covers in every other FBS matchup in Week 4, and it's calling for several underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned nearly $2,500 in profit since its inception, and find out.

College football odds for top Week 4 games 

See full Week 4 college football picks, odds, predictions here

Saturday, Sept. 23

Oklahoma at Cincinnati (+14, 57.5)

Florida State at Clemson (+2.5, 55)

Ole Miss at Alabama (-7, 56)

UCLA at Utah (-3.5, 52)

Colorado at Oregon (-21, 70)

Arkansas at LSU (-17.5, 55)

Ohio State at Notre Dame (+3.5, 55.5)

Iowa at Penn State (-14, 38.5)

Texas at Baylor (+17, 48.5)

North Carolina at Pittsburgh (+7.5, 50)