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The Washington Football team will take on the Carolina Panthers on Sunday, and in a turn of events no one would have predicted before the season, it'll feature one of the more intriguing quarterback matchups you'll see. Washington will start Taylor Heinicke, while the Panthers will trot out Cam Newton after signing him last week. The Panthers are 3.5-point favorites in the latest Week 11 NFL odds from Caesars Sportsbook.

What should bettors think of one of the tightest NFL spreads of the week and of the quarterbacks participating in this game? It's one of seven Week 11 NFL Vegas lines under four points, and a point total of 43 indicates it could be a low-scoring game. All of the Week 11 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 11 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 11 of the 2021 season on an incredible 128-89 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 11 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 11 NFL predictions

One of the model's strongest Week 11 NFL picks is that the Titans (-10) cover the spread against the Texans with points to spare. The Titans have been the hottest team in the NFL over the past month, bringing a six-game winning streak into this contest. They have not missed a beat since losing star running back Derrick Henry to a foot injury. Tennessee barely failed to cover the spread in a 23-21 win over New Orleans last Sunday, but had covered its previous five games.

Wide receiver Marcus Johnson caught five passes for 100 yards, bursting onto the scene after catching just four passes the rest of the season. The Titans face a Houston defense that ranks No. 29 in scoring defense and No. 30 in total defense. Quarterback Ryan Tannehill has completed 66.5 percent of his passes and should have plenty of success on Sunday.

SportsLine's model projects Tannehill to throw for more than 285 yards and two touchdowns. Tennessee is covering the spread in well over 60 percent of simulations.

Another one of its Week 11 NFL predictions: The Steelers (+6) cover against the Chargers. While some shine is off the Steelers after they weren't able to beat a winless Lions team last week, the Chargers are also trending downward after their strong start. Justin Herbert has passed for only 182, 206 and 171 yards in the Chargers' last three losses, which have come in three of their last four games. The Steelers, meanwhile, have been playing lockdown defense and have only allowed two opponents to exceed 251 yards through the air.

The Steelers cover in almost 60 percent of simulations from SportsLine's model, which is why they're one of the top NFL picks. They don't have to win to cover, but the model says Pittsburgh wins outright in well over 40 percent of simulations. The point total sits at 47, and that goes under in almost 60 percent of simulations.

How to make Week 11 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 11 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,500 since its inception, and find out.

Week 11 NFL odds, spreads, lines

Sunday, Nov. 21

Lions at Browns (-12, 42.5)

Featured Game | Cleveland Browns vs. Detroit Lions

49ers at Jaguars (+6.5, 45)

Featured Game | Jacksonville Jaguars vs. San Francisco 49ers

Colts at Bills (-7, 49.5)

Featured Game | Buffalo Bills vs. Indianapolis Colts

Dolphins at Jets (+3.5, 44.5)

Featured Game | New York Jets vs. Miami Dolphins

Washington Football Team at Panthers (-3.5, 43)

Featured Game | Carolina Panthers vs. Washington Commanders

Ravens at Bears (+6, 44.5)

Featured Game | Chicago Bears vs. Baltimore Ravens

Saints at Eagles (-2.5, 42.5)

Featured Game | Philadelphia Eagles vs. New Orleans Saints

Texans at Titans (-10, 44.5)

Featured Game | Tennessee Titans vs. Houston Texans

Packers at Vikings (+1, 47)

Featured Game | Minnesota Vikings vs. Green Bay Packers

Bengals at Raiders (+1, 50.5)

Featured Game | Las Vegas Raiders vs. Cincinnati Bengals

Cowboys at Chiefs (-2.5, 56.5)

Featured Game | Kansas City Chiefs vs. Dallas Cowboys

Steelers at Chargers (-6, 47)

Featured Game | Los Angeles Chargers vs. Pittsburgh Steelers

Monday, Nov. 22

Giants at Buccaneers (-11, 49.5)

Featured Game | Tampa Bay Buccaneers vs. New York Giants