A pair of teams battling for the top seed in the NFL playoff picture will square off Sunday afternoon when the Packers host the Rams at Lambeau Field during the Week 12 NFL schedule. Green Bay is currently in second place in the conference following its loss at Minnesota last week, while Los Angeles will hope to recover from a two-game losing skid. The Rams are 1.5-point road favorites in the latest Week 12 NFL odds at Caesars Sportsbook.

Another game involving one of the top teams in the NFC will take place when Tampa Bay travels to Indianapolis. The Buccaneers snapped a two-game skid with a 30-10 win over the Giants last week and are a field goal favorite in the current NFL spreads. All of the Week 12 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 12 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 12 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 12 NFL predictions

One of the model's strongest Week 12 NFL picks is that the Steelers (+3.5) cover the spread against the Bengals. The Steelers had their five-game unbeaten streak snapped in a 41-37 loss to the Chargers last week, but they are still in contention for the AFC North title. Pittsburgh was decimated by injuries heading into that game, but could get several key players back on Sunday.

Linebacker T.J. Watt and safety Minkah Fitzpatrick are both active and will return from injuries in this game. The Steelers will be able to put pressure on Joe Burrow, especially with Watt back on the field. Running back Najee Harris has burst onto the scene over the last few months, providing a spark for Pittsburgh's offense. SportsLine's model expects Harris to go over 80 yards and score a touchdown against Cincinnati. The Steelers cover the spread in well over 50 percent of simulations. 

Another one of its Week 12 NFL predictions: The Patriots (-7) cover against the Titans. The Patriots are the hottest team in the NFL, rattling off five consecutive wins coming into this week's game. They opened as 2.5-point home favorites, but are now seven-point favorites following Tennessee's shocking loss to Houston. The Titans were unable to overcome a four-interception game from quarterback Ryan Tannehill, who will be without his top two receivers.

New England's defense has allowed an average of just 169.6 passing yards per game during the five-game winning streak. The Patriots have outscored their opponents 175-50 over that span. SportsLine's model says New England covers the spread in more than 50 percent of simulations. The over (44) also cashes more than 50 percent of the time. 

How to make Week 12 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 12 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,300 since its inception, and find out.

Week 12 NFL odds, spreads, lines

Sunday, Nov. 28

Titans at Patriots (-7, 43.5)

Featured Game | New England Patriots vs. Tennessee Titans

Jets at Texans (-2.5, 45)

Featured Game | Houston Texans vs. New York Jets

Eagles at Giants (+3.5, 45.5)

Featured Game | New York Giants vs. Philadelphia Eagles

Buccaneers at Colts (+3, 53)

Featured Game | Indianapolis Colts vs. Tampa Bay Buccaneers

Falcons at Jaguars (+2, 46)

Featured Game | Jacksonville Jaguars vs. Atlanta Falcons

Panthers at Dolphins (+2.5, 42)

Featured Game | Miami Dolphins vs. Carolina Panthers

Steelers at Bengals (-3.5, 44)

Featured Game | Cincinnati Bengals vs. Pittsburgh Steelers

Chargers at Broncos (+2.5, 47)

Featured Game | Denver Broncos vs. Los Angeles Chargers

Vikings at 49ers (-3, 49)

Featured Game | San Francisco 49ers vs. Minnesota Vikings

Rams at Packers (+1.5, 47)

Featured Game | Green Bay Packers vs. Los Angeles Rams

Browns at Ravens (-3.5, 47)

Featured Game | Baltimore Ravens vs. Cleveland Browns

Monday, Nov. 29

Seahawks at Washington (PK, 46.5)

Featured Game | Washington Football Team vs. Seattle Seahawks