NFL odds, lines, picks, spreads, best bets, predictions, office pool, best survivor picks for Week 15, 2022

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As the Week 15 NFL schedule continues on Sunday, several teams are separating themselves as 2023 Super Bowl contenders. The latest Week 15 NFL odds from Caesars Sportsbook show the widening gap between the top contenders and the rest of the league. The Kansas City Chiefs are the week's biggest favorites at -14.5 against the one-win Houston Texans in the NFL spreads. Other large Week 15 NFL betting lines include Eagles (-9) against the Bears and Packers (-7) against the Rams. All of the Week 15 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 15 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 15 NFL odds and locked in NFL picks for every NFL matchup. Head here to see every pick.

Top Week 15 NFL predictions

One of the model's strongest Week 15 NFL picks is that the Jets (-1) cover the spread at home against the Lions. New York has lost three of its last four games, but all three of those losses came on the road. The Jets have won three of their last four home games, beating Miami, Buffalo and Chicago, so they will be confident coming into this matchup. Detroit has not played a road game since Nov. 20, making this a difficult scheduling spot.

The Lions have gone 2-12-1 in their last 15 road games and quarterback Jared Goff will face the fourth-best pass defense in the NFL. New York is facing a weak Detroit defense, which will allow the Jets to get back on track offensively. They have covered the spread in seven of their last 10 games, making them one of the most undervalued teams in the league this season. SportsLine's model has New York covering the spread almost 60% of the time in this matchup. See which other teams to pick here.

Top Week 15 NFL survivor picks

The model's Week 15 NFL knockout pool picks say to avoid the Falcons (5-8), even though they are a game ahead of the Saints (4-9) in the NFC South. Falcons quarterback Marcus Mariota hasn't thrown for 200 yards in a game since Week 8 and has only done so three times total this season. Atlanta has been more committed to running the ball, but the Saints have held opponents to fewer than 100 rushing yards six times this year.

Saints rookie wide receiver Chris Olave leads all first-year pass-catchers with 887 receiving yards this season and has over 350 more receiving yards than Atlanta first-rounder Drake London. The Falcons have allowed the sixth-most passing yards in the NFL, and Olave should feast at home, which is why the model recommends looking elsewhere in your NFL survivor pool picks. See which team you should pick here.

Top Week 15 NFL office pool picks

One of the strongest Week 15 NFL football pool picks from the model is that the Chiefs beat the Texans. The Texans nearly pulled off one of the biggest upsets of the season last week against the Cowboys. Dallas used a 98-yard drive to avoid suffering a loss as a 17-point favorite. The Chiefs will have studied that game and won't take the Texans lightly this week.

The Chiefs feature the league's most potent offense, averaging 423.8 yards per game. Kansas City is averaging 309.2 passing yards per game, while the Texans rank dead-last in total offense (283.0). SportsLine's model is projecting Kansas City quarterback Patrick Mahomes to throw for 348 yards and 2.40 touchdowns on Sunday, helping the Chiefs win straight-up in almost 80% of simulations. See which other teams to pick here.

How to make Week 15 NFL picks

The model has made the call on who wins and covers in every other game on the Week 15 NFL schedule, and it's calling for a shocking loss by a home favorite. It's also backing a surprising team that's turned the corner in its NFL survivor picks. You can only get every pick for every game at SportsLine.

So what NFL predictions, NFL pool picks, and NFL survivor picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $7,000 since its inception, and find out.