NFL odds, lines, picks, spreads, bets, predictions for Week 10, 2023: Model backing Bills, 49ers

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If the season ended today, every team from the AFC North would make the playoffs. If that were to happen, the AFC North would become the first division to send all four teams to the playoffs in the same season. The Baltimore Ravens enter Week 10 on top of the AFC North standings with a 7-2 record. On Sunday, Lamar Jackson and the Ravens will renew their rivalry with the Cleveland Browns in an AFC North showdown. According to the latest Week 10 NFL odds from the SportsLine consensus, the Ravens are favored by six points at home.

Should your Week 10 NFL bets include backing the Ravens to cover one of the largest NFL spreads of the week or are you better off targeting another favorite like the Lions (-3) on the road against the Chargers? All of the Week 10 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 10 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2023 NFL season on an incredible 174-123 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 28-15 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 10 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 10 NFL predictions

We can tell you one of the model's strongest Week 10 NFL picks is that the Bills (-7.5) cover at home against the Broncos. Buffalo has struggled in recent weeks, losing two of its last three games. The Bills are in jeopardy of missing the playoffs if this slide continues, but playing the Broncos at home is the perfect bounce-back spot for Sean McDermott's team.

Denver is 1-7 in its last eight games on the road and the Broncos are 1-6 against the spread in their last seven games on the road against the Bills. In addition, Buffalo is 16-3 in its last 19 games at home. Despite their recent slump, the Bills are still averaging 370.2 yards per game on offense, the fifth-most in the NFL. Josh Allen and company will now square off against a Broncos defense that's giving up 405.9 yards per game this season, which ranks dead-last in the league. SportsLine's model projects Allen will finish with more than 300 all-purpose yards on Monday, a big reason why Buffalo (-7.5) covers the spread in nearly 60% of simulations. See which other teams to pick here.

Another one of its Week 10 NFL predictions: The 49ers (-3) cover the spread on the road versus the Jaguars. The 49ers are loaded with playmakers and their defense is among the best in the NFL. San Francisco's defense is giving up just 17.5 points per game, which ranks fourth in the league.

The 49ers are coming off their bye week after losing three straight games, so they'll enter Sunday's showdown with Jacksonville fresh. Offensively, the 49ers are led by running back Christian McCaffrey. The veteran ball-carrier has scored at least once in all eight contests thus far this season and is averaging 4.8 yards per carry. In addition, San Francisco is 5-0 against the spread in its last five games against Jacksonville. SportsLine's model shows the 49ers getting back into the win column and covering the spread in over 50% of simulations on Sunday. See which other teams to pick here.

How to make Week 10 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 10 NFL schedule and also just revealed two coveted A-rated picks. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence, and which A-rated picks can you place right now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 since its inception, and find out.