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The Kansas City Chiefs are the reigning Super Bowl champions and despite a lackluster start to the season offensively, they're 5-1 heading into a Week 7 matchup with the Los Angeles Chargers. Kansas City's defense has been doing a lot of the heavy lifting, as the Chiefs rank second in scoring defense (14.7 points per game). Patrick Mahomes, Travis Kelce, and company are 5.5-point favorites in the Week 7 NFL odds from the SportsLine Consensus. Meanwhile, the Eagles are also 5-1 after losing by three points in the Super Bowl to the Chiefs last season, but they're only three-point favorites at home against the 5-1 Dolphins after suffering their first loss a week ago.

Which side should you back with your NFL bets and what other Week 7 NFL spreads should you target? All of the Week 7 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 7 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2023 NFL season on an incredible 172-120 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 26-12 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 7 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 7 NFL predictions

We can tell you one of the model's strongest Week 7 NFL picks is that the Ravens (-3) cover at home against the Lions. The Lions are one of the NFL's biggest surprises at 5-1, but they'll face their toughest test since a Week 1 win over the Chiefs on Sunday in Baltimore.

The Ravens are 4-2 and have one of the NFL's best defenses. Baltimore ranks fourth in scoring defense (15.2 points per game) and second in total defense (260.8 yards per game) through the first six weeks. The Ravens have been dominant against the pass, ranking second in pass defense and first in net adjusted yards per pass attempt (4.0) thanks to a league-leading 24 sacks. That's a big reason why the model that Baltimore covers in over 50% of simulations. See which other teams to pick here.

Another one of its Week 7 NFL predictions: The Rams (-3) cover the spread at home versus the Steelers. Los Angeles' offense has been effective early this season, averaging 367.0 yards per game. Quarterback Matthew Stafford has a plethora of weapons, including veteran Cooper Kupp and rookie Puka Nacua, who's already racked up 50 receptions for 598 yards and two touchdowns.

The Steelers are anemic offensively, ranking 30th in the league with just 268.2 yards per game. In addition, the Rams are 5-1 against the spread in their last five games at home. SportsLine's model projects Los Angeles' defense will limit Pittsburgh's offense to 19 points on Sunday, a big reason why the Rams cover the spread over 50% of the time. See which other teams to pick here.

How to make Week 7 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 7 NFL schedule and revealed three coveted A-rated picks. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence, and which A-rated picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 since its inception, and find out.

Week 7 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Oct. 22

Lions at Ravens (-3, 43)

Raiders at Bears (+2.5, 38)

Browns at Colts (+3.5, 40.5)

Bills at Patriots (+7.5, 40)

Commanders at Giants (+3, 37.5)

Falcons at Buccaneers (-2.5, 37)

Steelers at Rams (-3, 43.5)

Cardinals at Seahawks (-8, 44.5)

Packers at Broncos (+1, 45)

Chargers at Chiefs (-5.5, 47.5)

Dolphins at Eagles (-3, 52)

Monday, Oct. 23

49ers at Vikings (+6.5, 44)