The Seattle Seahawks and Green Bay Packers have destroyed NFL spreads through three weeks, both going 3-0 against the number. Both teams have a realistic shot at moving to 4-0 on the season with their Week 4 NFL matchups. The latest Week 4 NFL odds from William Hill list Seattle as a 5.5-point road favorite against Miami, with Green Bay listed as a seven-point home favorite against the Falcons on Monday Night Football.

The Texans, meanwhile, have been the worst team in the league thus far against NFL Vegas lines. They're 0-3 against the spread and have struggled mightily through the first three weeks. They'll look to bounce back as 3.5-point favorites in the Week 4 NFL point spreads at home against the winless Minnesota Vikings. Where is the value in the NFL betting lines this week? All of the Week 4 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 4 NFL picks now.

The SportsLine Projection Model simulates every NFL game 10,000 times and is up over $7,500 for $100 players on its top-rated NFL picks since its inception five years ago.

It's off to a strong 7-2 roll on top-rated NFL picks this season. The model enters Week 4 on an incredible 103-67 roll on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, it has examined the latest Week 4 NFL odds and NFL betting lines, simulated every snap, and its predictions are in. Head to SportsLine now to see them all.

Top NFL predictions for Week 4

One of the top Week 4 NFL predictions the model recommends: The Cowboys (-4.5) cover at home against the Browns. Dallas is off to a disappointing 1-2 straight-up start with an 0-3 mark against the spread. That's the worst start against the spread for the Cowboys since 1989, when they began 0-6. 

However, the Browns have only covered once this season and own a minus-4.3 point differential. The Browns failed to cover their only road game so far as well as their only game as an underdog. SportsLine's model is calling for a convincing 10-point Cowboys win that covers the spread in 60 percent of simulations. There's also value on the under (56), which hits 56 percent of the time.

Another one of the top Week 4 NFL picks from the model: The Seahawks cover as 5.5-point road favorites against the Dolphins at Hard Rock Stadium. The Seahawks are off to a blistering 3-0 start thanks in large part to the play of quarterback Russell Wilson.

He has been sensational through the first three weeks of the season, throwing for 925 yards and 14 touchdowns. He's thrown four or more touchdown passes in every game this season and will now try to dissect a Miami defense that's giving up 399.3 yards per game.

In addition to Wilson's spectacular play this season, the Seahawks have been dominant on the road. In fact, Seattle is 9-2 in its last 11 games on the road. SportsLine's model says Wilson and the Seahawks cover in nearly 60 percent of simulations on Sunday. 

How to make Week 4 NFL picks 

The model also has made the call on the huge Chiefs vs. Patriots matchup as well as every other game on the Week 4 NFL schedule. It's also identified a Super Bowl contender that goes down hard. You can only get every pick for every game at SportsLine.

What NFL picks can you make with confidence in Week 4? And which Super Bowl contender goes down hard? Check out the latest NFL odds from William Hill below and then visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, all from the model that is up over $7,500 on its top-rated NFL picks

NFL odds, matchups for Week 4

Indianapolis Colts at Chicago Bears (+2.5, 43)
New Orleans Saints at Detroit Lions (+3, 54)
Arizona Cardinals at Carolina Panthers (+3, 51.5)
Jacksonville Jaguars at Cincinnati Bengals (-2.5, 49)
Cleveland Browns at Dallas Cowboys (-4.5, 56)
Minnesota Vikings at Houston Texans (-3.5, 54.5)
Seattle Seahawks at Miami Dolphins (+5.5, 54)
Los Angeles Chargers at Tampa Bay Buccaneers (-7, 42.5)
New York Giants at Los Angeles Rams (-13, 48)
Buffalo Bills at Las Vegas Raiders (+3, 53)
Philadelphia Eagles at San Francisco 49ers (-7, 45)
Baltimore Ravens at Washington (+14, 45)
New England Patriots at Kansas City Chiefs (off the board)
Atlanta Falcons at Green Bay Packers (-7, 56.5)