NFL odds, lines, picks, spreads, bets, predictions for Week 10, 2021: Model backing Bills, Broncos

Dallas failed to cover the spread for the first time this season in a shocking blowout loss to Denver last week. The Cowboys had covered in their first seven games and were 10-point favorites. The Broncos jumped out to a 16-0 lead at halftime and would eventually lead 30-0 before allowing two late scores. Dallas will try to bounce back during the Week 10 NFL schedule when it hosts Atlanta on Sunday. The Cowboys are nine-point favorites in the latest Week 10 NFL odds at Caesars Sportsbook.

Atlanta has won three out of its last four games after picking up a road win at New Orleans, so is the game one of the Week 10 NFL spreads that you should target? All of the Week 10 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 10 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 10 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 10 NFL predictions

One of the model's strongest Week 10 NFL picks is that the Bills (-12) cover the spread against the Jets. Buffalo is coming off a head-scratching loss to Jacksonville last week, as the offense was unable to score a touchdown in a 9-6 final. New England is now tied with the reigning AFC East champions at the top of the division following a three-game winning streak. The Bills cannot afford another loss to an inferior team, so they should be ready to go on Sunday.

New York is without starting quarterback Zach Wilson, while backup Mike White is also dealing with a forearm injury. Quarterback instability does not bode well against a Buffalo defense that has allowed a league-low 118 points and 262.6 yards per game. The Bills still rank eighth offensively in yards per game (390.1), even after their abysmal outing last week.

SportsLine's model is projecting nearly 300 passing yards and two touchdowns for Bills quarterback Josh Allen on Sunday. The Bills are covering the spread in well over 60 percent of simulations, while the under (47.5) is hitting nearly 60 percent of the time.

Another one of the model's Week 10 NFL predictions: The Broncos (-2.5) cover against the Eagles at home. The Broncos went on a four-game losing streak last month, but they have bounced back with wins over Washington and Dallas. They took a 30-0 lead over the Cowboys last week before allowing two late touchdowns. Quarterback Teddy Bridgewater passed for 249 yards and one score in the win.

Denver's rushing attack added 190 yards and two touchdowns on 41 carries. Rookie Javonte Williams had a career-high 111 yards on 17 attempts in a balanced effort from the offense. Bridgewater had thrown five interceptions during a three-game stretch, but he has now turned in two consecutive clean performances.

Philadelphia has gone winless straight-up and against the spread in its three games against AFC West opponents. SportsLine's model expects that to continue on Sunday, as the Broncos cover the spread in well over 50 percent of simulations.

How to make Week 10 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 10 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,600 since its inception, and find out.