NCAA Football: Texas A&M at Alabama

No. 10 Wake Forest can clinch its first ACC Atlantic Division title since 2006 when it travels to Clemson on Saturday during the Week 12 college football schedule. Clemson remains mathematically alive in the Atlantic, however, and it brings a three-game winning streak into this game following a blowout win over UConn. The Tigers are 4.5-point home favorites in the latest Week 12 college football odds at Caesars Sportsbook.

Elsewhere, No. 4 Ohio State is a 19-point favorite against No. 7 Michigan State and No. 3 Oregon is a three-point underdog at No. 24 Utah. Should you be looking at either of these Week 12 college football spreads? And which other college football lines have value on Saturday? Before making any Week 12 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 12 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 12 college football predictions

One of the top college football picks the model is recommending for Week 12: No. 18 Pittsburgh (-14.5) covers at home against Virginia in a 3:30 p.m. ET ACC matchup. The Panthers are in the midst of their best season in recent memory, even if expectations might be slightly lower now than they were a few weeks ago. They have arguably the best quarterback in the conference in Kenny Pickett, and have a spot in the ACC Championship Game locked up if they can win on Saturday.

In simulations from SportsLine's model, Pitt takes home the cover well over 50 percent of the time. The model projects another monster game for Pickett with 350 yards through the air and at least two touchdowns. While Virginia has boasted an impressive offense this season, SportsLine's model has the under 66 hitting in almost 60 percent of simulations.

Another one of the college football predictions from the model: No. 6 Michigan (-15) covers the two-score spread at Maryland in a 3:30 p.m. ET Big Ten battle. The Wolverines responded from their disappointing loss to then-No. 8 Michigan State with wins over Indiana and Penn State. Michigan running back Hassan Haskins ranks third in the Big Ten with 985 rushing yards.

Haskins rushed a career-high 31 times for 156 yards against Penn State. Maryland's defense has allowed at least 30 points in six consecutive games, so Haskins should have another big day. SportsLine's model has Michigan covering the spread in over 60 percent of simulations, while the under (57.5) is also hitting more than 60 percent of the time. 

How to make Week 12 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 12 college football schedule, and it's predicting an upset that will have a big impact on the College Football Playoff chase. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdog do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,500 in profit over the past five-plus seasons, and find out.

Week 12 college football odds (via Caesars)

Here are the college football lines for some of Week 12's most notable matchups:

Saturday, Nov. 20

Wake Forest vs. Clemson (-3.5, 55.5.)

Featured Game | Clemson Tigers vs. Wake Forest Demon Deacons

Michigan State vs. Ohio State (-19, 66.5)

Featured Game | Ohio State Buckeyes vs. Michigan State Spartans

Iowa State vs. Oklahoma (-4, 59.5)

Featured Game | Oklahoma Sooners vs. Iowa State Cyclones

Notre Dame vs. Georgia Tech (+15.5, 59.5)

Featured Game | Notre Dame Fighting Irish vs. Georgia Tech Yellow Jackets

SMU vs. Cincinnati (-12, 64.5)

Featured Game | Cincinnati Bearcats vs. SMU Mustangs

Michigan vs. Maryland (+14.5, 55.5)

Featured Game | Maryland Terrapins vs. Michigan Wolverines

Virginia vs. Pittsburgh (-13.5, 64.5)

Featured Game | Pittsburgh Panthers vs. Virginia Cavaliers

Alabama vs. Arkansas (+20.5, 56)

Featured Game | Alabama Crimson Tide vs. Arkansas Razorbacks

Baylor vs. Kansas State (pick'em, 50)

Featured Game | Kansas State Wildcats vs. Baylor Bears

Ole Miss vs. Vanderbilt (+36.5, 64)

Oregon vs. Utah (-3, 58.5)

Featured Game | Utah Utes vs. Oregon Ducks

Oklahoma State vs. Texas Tech (+10.5, 56.5)

Featured Game | Texas Tech Red Raiders vs. Oklahoma State Cowboys