There are a number of NFL betting trends that should be of high interest to anyone making Week 2 NFL picks. Seattle is 1-9 against the spread over its last 10 games, including the playoffs, and now heads to Detroit to face a Lions team with the inverse ATS record. Detroit is 9-1 against the spread over its last 10, the best record in the league over that span. However, before backing the Lions with your Week 2 NFL bets, you should also know that the Seahawks have both won and covered in the last three meetings between these teams. Detroit is a 4.5-point favorite in the latest Week 2 NFL odds. All of the Week 2 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 2 NFL picks now

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. 

Now, it has turned its attention to the latest Week 2 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 2 NFL predictions

One of the model's strongest Week 2 NFL picks is that the Buccaneers (-2.5) cover against the Bears in a 1 p.m. ET kickoff on Sunday. Tampa has won and covered in its last three home games versus Chicago, including in 2021 when Justin Fields started for the Bears.

Fields has lost his last nine starts as part of an overall 11-game losing streak for Chicago. The young quarterback has covered in just two of those nine starts, but both of those ATS wins came at home. He still hasn't quite figured out how to deal with the pass rush, as he's been sacked 62 times over his last 17 starts, which would be the fifth-most in NFL history in a single season.

Tampa ranked seventh in the NFL in sacks last season and the model has it getting to Fields at least four times. Chicago's offense isn't built to overcome those setbacks as the Bucs (-2.5) are projected to cover well over 50% of the time. See which other teams to pick here.

Another one of its Week 2 NFL predictions: the Cardinals (+4) cover the spread at home versus the Giants. Arizona didn't acquire current starting quarterback Joshua Dobbs until late in the preseason, but felt like his athleticism made him a better fit in an offense that typically features Kyler Murray.

In Week 1, Dobbs focused on protecting the football and ultimately helped the defense keep the Cardinals in the game. They led in the fourth quarter and ultimately covered as seven-point road underdogs against the Commanders, with the defense recording six sacks and forcing three turnovers.

Now, they'll take on a Giants squad that was blasted 40-0 on Sunday Night Football by the Cowboys in Week 1. New York only managed 171 yards of total offense and Daniel Jones threw two interceptions while being sacked seven times. The model says Arizona's defense causes Jones more issues, predicting four sacks and multiple turnovers to help Arizona cover in nearly 60% of simulations. See which other teams to pick here.

How to make Week 2 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 2 NFL schedule, and it's identified two must-see underdogs who pull off upsets. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence, and which heavy underdogs should you back? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,000 since its inception, and find out.

Week 2 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Sept. 17

Packers at Falcons (-2.5, 40)

Raiders at Bills (-8, 47)

Ravens at Bengals (-3, 45.5)

Seahawks at Lions (-4.5, 47)

Colts at Texans (-1, 39.5)

Chiefs at Jaguars (+3, 51)

Bears at Buccaneers (-2.5, 40)

Chargers at Titans (+2.5, 45)

Giants at Cardinals (+4, 39.5)

49ers at Rams (+7.5, 45.5)

Jets at Cowboys (-8.5, 38.5)

Commanders at Broncos (-4, 38.5)

Dolphins at Patriots (+2.5, 46.5)

Monday, Sept. 18

Saints at Panthers (+3, 39.5)

Browns at Steelers (+2.5, 38.5)