College football odds, picks, top predictions, best bets for Week 10: Proven computer likes Clemson, Auburn

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No. 1 Tennessee will be looking to stay on top of the College Football Playoff Rankings when it travels to No. 3 Georgia on Saturday afternoon in a 3:30 p.m. SEC on CBS matchup during the Week 10 college football schedule. The betting market is not buying the Vols as the best team in the country, making Georgia a 9-point home favorite in the latest Week 10 college football odds at Caesars Sportsbook. The Bulldogs are the defending national champions and have won the past five meetings between these teams. Should you be backing them to cover the spread against the top scoring offense in the country with your Week 10 college football bets?

Another important SEC battle features No. 10 LSU hosting No. 6 Alabama in a game that could decide the SEC West winner. The Crimson Tide are 13.5-point road favorites in the latest Week 10 college football lines. Before making any Week 10 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 10 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 10

One of the college picks the model is high on in Week 10: No. 4 Clemson (-3.5) cruises to an easy win at Notre Dame on Saturday night. The Tigers might be riding a 14-game winning streak, but they are still not getting as much credit as they deserve in the betting market. They have covered large spreads in three of their last four games and have extra rest coming into this weekend off their open date.

Notre Dame has been extremely inconsistent this season, which has resulted in outright losses to Marshall and Stanford along with a close call against California. The Fighting Irish had to play a road game at then-No. 16 Syracuse last week, putting them at a disadvantage against a rested team. Clemson quarterback DJ Uiagalelei has thrown 13 touchdown passes in his last three road games, while running back Will Shipley has averaged 146.5 rushing yards in his last two games. The Tigers have too much offensive firepower for Notre Dame to match, which is one reason why they are covering the spread in well over 60% of the latest simulations.

Another one of the model's top college football picks: Auburn (+12.5) stays within the two-score spread when it travels to Mississippi State at 7:30 p.m. ET on Saturday. The Tigers have dominated this series over the past two decades, winning 14 of the last 20 meetings. They have also covered the spread in four of their last six games against the Bulldogs, despite being favored in all six of those contests.

Auburn was a 5.5-point favorite when these teams met last season, making this large spread look like an overreaction. The Tigers should get a spark from interim head coach Cadillac Williams, who took over following Bryan Harsin's firing earlier this week. He has done an excellent job coaching running back Tank Bigsby throughout the season, and the model expects Bigsby to rush for more than 70 yards on Saturday night. His success is one reason why the Tigers are covering the spread almost 70% of the time. See which other teams the model likes here.

How to make college football picks for Week 10

The model has also made the call on who wins and covers in every other FBS matchup in Week 10, and it says several top-25 teams will go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-25 teams go down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past six-plus seasons, and find out.