NCAA Football: Texas A&M at Alabama
Gary Cosby Jr / USA TODAY Sports

After two dominant wins to open their season, the Wisconsin Badgers suffered their first setback in a 17-7 defeat against Northwestern on Nov. 21. Quarterback Graham Mertz struggled mightily in Wisconsin's loss, completing 23-of-41 pass attempts for 230 yards and three interceptions. The Week 14 college football odds from William Hill Sportsbook lists No. 16 Wisconsin as a 14-point favorite at home against No. 12 Indiana, who will turn to quarterback Jack Tuttle due to Michael Penix Jr.'s knee injury. Wisconsin enters Saturday's Big Ten battle having won 10 consecutive meetings against the Hoosiers.

Should you target Indiana vs. Wisconsin or look elsewhere for your best bets on the week 14 college football schedule? And which week 14 college football spreads present the best value? Before making any Week 14 college football picks on that game or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It is a sizzling 49-25 on all top-rated picks through 13 weeks of the 2020 college football season, returning almost $1,300 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Week 14 from William Hill and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 14 college football predictions 

One of the top Week 14 college football picks the model is recommending: No. 6 Florida (-17.5) covers on the road against Tennessee in a 3:30 p.m. ET SEC on CBS matchup. The Gators have won five in a row by 16 or more points and have gone 3-1-1 against the spread during that span. Tennessee, meanwhile, has dropped five straight and has failed to cover in all those games.

The Gators have also won 14 of their last 15 against Tennessee and have blown the Vols out by 26 or more points in their last two meetings. The simulations show Heisman candidate Kyle Trask throwing for well over 300 yards for the Gators. They pick up the cover in over 60 percent of simulations. The under (62.5), meanwhile, hits 60 percent of the time. 

Another one of the top Week 14 college football predictions from SportsLine's model: Purdue covers at home as the Boilermakers take on the Nebraska Cornhuskers (+1) at noon ET on Saturday.

Purdue limps into Saturday's contest having lost three straight games. Despite their recent losing skid, the Boilermakers have found their offensive prowess, scoring 30 or more points in three of their last four outings. Purdue has a lot of talent at receiver and is also getting good production from running back Zander Horvath, who is coming off a strong performance against Rutgers, a game in which he rushed for 101 yards and a touchdown. He's eclipsed the 100 yard rushing mark three times already this season, and he's averaging over five yards per carry.

Nebraska, meanwhile, has struggled mightily against Big Ten opponents. In fact, the Cornhuskers are 1-5 in their last six conference games. In addition, Nebraska is 1-4 against the spread in its last five games against Purdue. SportsLine's model shows Horvath averaging 4.5 yards per carry against Nebraska's rush defense, which is giving up over 200 yards per game on average, resulting in Purdue covering the spread in nearly 60 percent of simulations.

How to make Week 14 college football picks 

The model has also made the call on who wins and covers in every other Week 14 FBS matchup, and it is calling for a huge upset in the ACC. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 14? And which underdog should you be all over? Check out the latest Week 14 college football odds for some of the week's most notable games below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $3,500 in profit over the past four-plus seasons, and find out.

Week 14 college football odds (via William Hill)

Saturday, Dec. 5

Ohio State vs. Michigan State (+22.5)

Latest Odds: Ohio State Buckeyes -23.5

Texas vs. Kansas State (+9.5)

Latest Odds: Kansas State Wildcats +9

Texas A&M vs. Auburn (+6.5)

Latest Odds: Auburn Tigers +7

Syracuse vs. Notre Dame (-33.5)

Latest Odds: Syracuse Orange +33.5

Indiana vs. Wisconsin (-14)

Latest Odds: Indiana Hoosiers +14

BYU vs. Coastal Carolina (+10.5)

Latest Odds: Coastal Carolina Chanticleers +10

Florida vs. Tennessee (+17.5)

Latest Odds: Florida Gators -17

Boston College vs. Virginia (-6)

Latest Odds: Boston College Eagles +6.5

Oregon vs. California (+9.5)

Latest Odds: Oregon Ducks -10

Clemson vs. Virginia Tech (+21.5)

Latest Odds: Clemson Tigers -22

Alabama vs. LSU (+28.5)

Latest Odds: LSU Tigers +29.5

Baylor vs. Oklahoma (-22)

Latest Odds: Oklahoma Sooners -22.5

Sunday, Dec. 6

Washington State vs. USC (-14)

Latest Odds: Washington State Cougars +13.5

Charlotte 24, Western Kentucky 23

Latest Odds: Charlotte 49ers -2.5