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Lincoln Riley created a stir in the offseason when he left Oklahoma to become the head coach of USC. Many were surprised, and the decision by many former Sooners players to join him in Southern California added even more emotion to the situation. The Trojans are massive 32.5-point favorites against Rice in their season-opener in the Week 1 college football odds at Caesars Sportsbook. Is USC an auto-pick for your college football office pool picks? The matchup is one of five during the opening weekend that features college football spreads of at least 30 points, and when making college football pool picks, those games can be some of the scariest to make picks on. Other intriguing Week 1 college football matchups featuring Pac-12 programs like No. 11 Oregon (+17) at No 3. Georgia and No. 7 Utah (-3) at Florida. If you're up for it, CBS Sports has the perfect game to keep you locked in all season long

Compete for $100,000 or start a college football pool with friends

It's time to raise the stakes with CBS Sports College Pick'em. Join the challenge to compete for the $100,000 jackpot and guaranteed cash prizes each week or start a customizable college football pool to compete against your friends.

You can win the $100,000 jackpot each week for hitting the full slate and tiebreakers. Even if no one hits the jackpot, CBS Sports is giving away a guaranteed $1,000 to the winner each week. In addition, the player with the most correct picks at the end of the season gets a guaranteed $5,000.

If you're looking to start a college football pick'em pool with your friends, family or colleagues, group settings include a variety of games suitable for every fan, including straight-up pick'em or against-the-spread picks. 

On the college side, you can choose your own slate of games or default to CBS Sports' top games. You can also choose whether to include conference championship week. You can play on your desktop or on the CBS Sports app, so sign up here today

Get football picks for every game from a proven college football model

We'll give you one team to consider backing during the college football's Week 1 schedule. SportsLine's advanced computer model, which simulates every FBS college football game 10,000 times, is predicting Mississippi State beats Memphis.

The Bulldogs felt the Mike Leach effect in 202,1 when they took to the air while going 7-6 in the rugged SEC West. Quarterback Will Rogers threw for 4,739 yards, 36 touchdowns and just nine interceptions. Rogers and most of the other primary players on offense will return in 2022. MSU was also sneakily effective on defense last season, giving up 25.9 points per game, which is fewer than some would expect for an Air Raid team.

Memphis, meanwhile, went just 6-6 last year and dropped six of its last nine games after opening the season on a three-game winning streak. Memphis won a tight 31-29 game between these teams last year, but SportsLine's model is calling the Bulldogs to get revenge in this spot. They win more than 60% of the time in the simulations, making the Bulldogs a team to back in your Week 1 college football pool picks.

Make college football pool picks at CBS Sports

Show your skills, beat your friends and coworkers, and take home guaranteed prize money. Create a pool, get your friends involved, and keep the competition going all season long