The DePaul Blue Demons head over to Carnesecca Arena as they match up against the St. John's Red Storm on Wednesday evening in a Big East affair. DePaul is 5-3 overall and has won two games in a row. St. John's owns an 8-1 record but picked up its first loss of the season on Sunday. The Red Storm leads the all-time series 29-22. These teams played three times last year, with St. John's securing victories in two of those games.

Tip-off is set for 6:30 p.m. ET. The Red Storm are 8.5-point favorites in the latest DePaul vs. St. John's odds from Caesars Sportsbook, while the over/under for total points scored is 158. Before locking in any St. John's vs. DePaul picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven computer model.  

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,400 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on DePaul vs. St. John's and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting lines and trends for St. John's vs. DePaul:

  • DePaul vs. St. John's spread: Red Storm -8.5
  • DePaul vs. St. John's over/under: 158 points 
  • DePaul vs. St. John's money line: Red Storm -420, Blue Demons +320
  • DEP: Blue Demons are 5-1 ATS in their last 6 Wednesday games
  • SJU: Red Storm are 5-1 ATS in their last 6 games following a straight-up loss
  • DePaul vs. St. John's picks: See picks at SportsLine
Featured Game | St. John's Red Storm vs. DePaul Blue Demons

Why St. John's can cover

Junior guard Andre Curbelo is an agile and skilled playmaker. Curbelo can be a crafty scorer who makes shots off the dribble. The Puerto Rico native has good lateral quickness and plays superb defense in the backcourt. Curbelo averages 11.3 points, 3.3 rebounds, 5.2 assists, and 2.1 steals per game. In the Nov. 29 win over Long Island University, he racked up 18 points, eight rebounds, and seven assists.

Senior guard Montez Mathis is a long and athletic force in the backcourt. Mathis can be lethal in transition due to his speed and power to get downhill. The Maryland native can finish through contact and rise above the rim. He's putting up 10.8 points, 2.6 rebounds, and 1.5 steals per contest. Mathis looks to drop 13-plus for the fifth time this season.

Why DePaul can cover

Senior forward Javan Johnson is a three-level scorer for this team. Johnson has the quickness to beat his man off the dribble and get into the paint. He can finish through contact and owns the vision to find the open man. The Alabama native has a nice jumper from downtown and forces defenses to consistently account for him. Johnson leads the team in scoring (18.4) and 3-point percentage (42). He's dropped 27-plus points in consecutive games. 

Senior guard Umoja Gibson is the floor general on the court. Gibson knows how to ignite the offense and get his teammates involved. He scans the floor well and uses screens to create space. The Texas native leads the team in assists (6.9) with 17.4 points per game. In his last game, Gibson dropped 23 points, four assists, and four steals. 

How to make St. John's vs. DePual picks

SportsLine's model is leaning Under on the total, projecting 152 combined points. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins DePaul vs. St. John's? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the spread you need to jump, all from the model that has crushed its college basketball picks, and find out.