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Programs on the upswing meet in Charlotte with a conference title on the line on Saturday night. The Pittsburgh Panthers, led by Heisman Trophy candidate quarterback Kenny Pickett, take on the Wake Forest Demon Deacons in the 2021 ACC Championship Game. Pitt is on a four-game winning streak with a 10-2 record this season. Wake Forest is 10-2 overall and 7-1 in conference play.

Caesars Sportsbook lists the Panthers as 3.5-point favorites for this 8 p.m. ET kickoff. The total number of points Vegas thinks will be scored, or the over-under, is 72 in the latest Pittsburgh vs. Wake Forest odds. Before locking in any Wake Forest vs. Pittsburgh picks, be sure to see the college football predictions and betting advice from SportsLine's proven model

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Pittsburgh vs. Wake Forest and just locked in its picks and ACC Championship Game predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting lines for Wake Forest vs. Pitt:

  • Pitt vs. Wake Forest spread: Pittsburgh -3.5
  • Pitt vs. Wake Forest over-under: 72 points 
  • Pitt vs. Wake Forest money line: Pittsburgh -160, Wake Forest +140
  • PITT: The Panthers are 9-3 against the spread in 2021 
  • WF: The Demon Deacons are 6-6 against the spread in 2021
Featured Game | Wake Forest Demon Deacons vs. Pittsburgh Panthers

Why Pittsburgh can cover

Pittsburgh's team-wide offensive numbers are jarringly impressive, with top-five national rankings in scoring offense and total offense in 2021. The Panthers are fully capable of garnering efficient yardage on the ground, but Pittsburgh really lives on its passing attack, headlined by one of the best quarterbacks in the nation in Pickett. Pickett is in the top five nationally in passing yards (4,066) and passing touchdowns (40), and he leads the ACC with a 67.7 percent completion rate. 

Pickett is averaging 8.8 yards per pass attempt this season, and he is experienced to the point where the big stage should not affect him. Pickett also has a tremendous No. 1 target in Jordan Addison, who leads the ACC with 1,353 receiving yards. Addison is also No. 1 in the nation with 17 receiving touchdowns, and he ranks No. 2 in the ACC with 85 catches this season.

Why Wake Forest can cover

Wake Forest is one of the most prolific scoring teams in the country, averaging more than 40 points per game. While that is a team effort for Dave Clawson and the Demon Deacons, Wake Forest also has some individual standouts. Quarterback Sam Hartman is enjoying a fantastic 2021 performance, throwing for more than 3,700 yards and tossing 34 touchdown passes. Hartman ranks No. 3 in the ACC in both yards and touchdowns, and he is also generating an impressive 8.8 yards per pass attempt. 

Wake Forest also has a pair of 1,000-yard wide receivers in A.T. Perry and Jaquarii Roberson. Perry leads the team with 1,112 receiving yards, and he is averaging 19.9 yards per reception with 13 touchdowns. Roberson has 1,024 receiving yards, posting 16.5 yards per catch with eight touchdown grabs. Wake Forest also has a very strong passing defense, and that will be of great importance against a high-powered Pittsburgh passing attack led by Pickett.

How to make Pittsburgh vs. Wake Forest picks

SportsLine's model is leaning under on the total, projecting the teams to combine for 71 points. The model also says one side of the spread hits in almost 60 percent of simulations. You can only see the model's Pitt vs. Wake Forest pick at SportsLine.

So who wins Pittsburgh vs. Wake Forest? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to see which side of the Pittsburgh vs. Wake Forest spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.