It's a Big 12 vs. SEC matchup when the No. 15 Kansas State Wildcats (2-0) head to Columbia to take on the Missouri Tigers (2-0) in one of the first kickoffs on Saturday. K-State has handled business in blowout victories over SE Missouri and Troy thus far, easily covering the spread in both those matchups. Missouri's 2-0 start has been shakier as the Tigers are 0-2 ATS and barely held off 21-point underdog MTSU last week in a 23-19 final. 

Kickoff is set for noon ET at Memorial Stadium at Faurot Field. SportsLine consensus lists the Wildcats as 3.5-point favorites in the latest Missouri vs. Kansas State odds. The over/under is 49.5, up 3.5 points from the opening line. Before locking in any Kansas State vs. Missouri picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on Kansas State vs. Missouri. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • Missouri vs. Kansas State spread: Kansas State -3.5
  • Missouri vs. Kansas State over/under: 49.5 points
  • Missouri vs. Kansas State money line: Kansas State -175, Missouri +146
  • Missouri vs. Kansas State picks: See picks here
  • Missouri vs. Kansas State live stream: fubo (try for free)

Why Missouri can cover

Missouri thrived as an underdog last season, going 5-3 ATS overall and 2-0 ATS at home in that situation. The Tigers have played both Brady Cook and Sam Horn at quarterback this season but Cook is settling in as the top choice. He's completed 77.5% of his passes for 376 yards and three touchdowns. He's added two scores on the ground.

Running back Cody Schrader has been a solid option in the backfield, rushing 41 times for 222 yards and a score. Luther Burden III is one of the most talented young receivers in the league and he leads the team with 15 catches for 213 yards and a score. 

Why Kansas State can cover

Missouri nearly lost as a 21-point favorite last week after failing to cover the spread in Week 1, and it is taking a major step up in competition this week. Kansas State has looked dominant through its first two games, covering the spread in blowout wins over Southeast Missouri State and Troy. The Wildcats blew out Missouri in a 40-12 final last season, giving them a mental edge in this game as well. 

Kansas State has scored 40-plus points in four straight regular-season games, led by senior quarterback Will Howard. He has thrown for 547 yards and accounted for eight total touchdowns. The Wildcats have been a profitable team since the middle of last season, covering the spread in six of their last seven games. They have also covered in four of their last five trips to Missouri. See which team to back here. 

How to make Missouri vs. Kansas State picks

The model has simulated Kansas State vs. Missouri 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Missouri vs. Kansas State, and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the Kansas State vs. Missouri spread to jump on, all from the advanced computer model that's up nearly $2,500 on its top-rated college football spread picks since its inception, and find out.