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The New York Knicks host the Los Angeles Lakers for an intriguing cross-conference matchup on Tuesday night. The Knicks are 9-8 this season, including a 4-5 mark at Madison Square Garden. The Lakers are 9-9 overall and 2-4 away from home in 2021-22. Derrick Rose (ankle) is questionable for the Knicks, with Taj Gibson (groin) listed as doubtful and Mitchell Robinson (concussion) ruled out. LeBron James (suspension) is out for the Lakers, as are Austin Reaves (hamstring), Kendrick Nunn (knee) and Trevor Ariza (ankle), while Anthony Davis (illness) is questionable.

Caesars Sportsbook lists the Knicks as 6.5-point favorites at home, and tip-off is scheduled for 7:30 p.m. ET. The total number of points Vegas thinks will be scored, or the over-under, is 214 in the latest odds. Before locking in any Knicks vs. Lakers picks or NBA predictions, be sure to check out what SportsLine's advanced computer model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 6 of the 2021-22 NBA season up over $1,200 on all top-rated NBA picks this season. It's also on a stunning 115-76 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen huge returns.

Now, the model has locked in on Lakers vs. Knicks and released its picks and predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds, betting lines and trends for Knicks vs. Lakers:

  • Lakers vs. Knicks spread: Knicks -6.5
  • Lakers vs. Knicks over-under: 214 points
  • Lakers vs. Knicks money line: Knicks -260, Lakers +210
  • LAL: The Lakers are 6-12 against the spread in the last 18 games
  • NYK: The Knicks are 7-10 against the spread in the last 17 games
Featured Game | New York Knicks vs. Los Angeles Lakers

Why the Lakers can cover

The Lakers have notable strengths on both ends, even facing roster challenges due to injury. Los Angeles is a top-10 team in field goal shooting at 46.1 percent, and the Lakers are also above league-average in 3-point shooting (34.8 percent) and free-throw attempts (20.7 per game). The Lakers are averaging 23.9 assists per game, a top-eight figure in the NBA, and New York has issues on the defensive glass with only a 71.3 percent defensive rebound rate this season. 

On the other end, Los Angeles is creating a turnover on 15.6 percent of possessions, and New York is a bottom-10 team in field goal percentage (44.1 percent) and 2-point percentage (49.9 percent). The Lakers can also contest shots well against the Knicks, with New York generating only 21.9 assists per game in the early going.

Why the Knicks can cover

New York's offense has been much improved this season. The Knicks are scoring nearly 1.09 points per possession in 2021-22, and Julius Randle is the clear leader of the attack. Randle is averaging 20.4 points, 10.0 rebounds and 5.1 assists per game, and he is flanked by perimeter shooting that provides adequate spacing. On top of New York's strengths, the Knicks can benefit from the weaknesses of the Lakers. Los Angeles is not at full strength from an injury standpoint, and the Lakers have a few offensive issues. 

Frank Vogel's team is second-worst in the NBA in ball security, committing 16.6 turnovers per game, and the Lakers fall in the bottom ten in free throw accuracy at 74.7 percent. On the other end, Los Angeles allows the second-most free throw attempts in the NBA (23.6 per game), and the Lakers are giving up 25.6 assists per game, fourth-worst in the NBA. Los Angeles is also a bottom-10 team in shooting efficiency allowed, and New York should be able to generate efficient looks.

How to make Knicks vs. Lakers picks

SportsLine's model is leaning under on the total, projecting the teams to combine for 204 points. The model also says one side of the spread has all of the value. You can only get the model's picks at SportsLine.

So who wins Lakers vs. Knicks? And which side of the spread has all of the value? Visit SportsLine now to see which side of the spread, all from the model that has crushed its NBA picks, and find out.