The Clemson Tigers come into the season ranked fourth in the nation, and they will try to make a statement on Monday night against the Georgia Tech Yellow Jackets. The 2022 Chick-fil-A Kickoff Game in Atlanta is a chance to prove that an offense that derailed last season is ready to shine. The Tigers went 10-3, but after six consecutive trips to the College Football Playoff – and two national titles – that was not good enough. The defense was one of the nation's best, and should remain so in 2022, so quarterback DJ Uiagalelei will need to show something Monday at Mercedes-Benz Stadium. Clemson also will be out to make amends for a poor showing in this matchup last year, when the Tigers had to fight for a 14-8 victory at home to continue their win streak against Georgia Tech. The Tigers have won seven in a row against their cross-division ACC rivals, who went 3-9 last season.  

Kickoff is set for 8 p.m. ET. The Tigers are 24-point favorites in the latest Clemson vs. Georgia Tech odds from Caesars Sportsbook, and the over/under for total points scored is 51. Before making any Georgia Tech vs. Clemson picks or Week 1 college football predictions, you need to see what SportsLine's Josh Nagel has to say.

Nagel is a Nevada-based handicapper with more than 20 years of experience in the sports wagering industry. Since the start of the 2018 college football season, he is 207-175-6 on all college football picks, returning a profit of $1,397. In addition, he has a particularly keen eye for the Tigers, going 6-0 on his picks involving Clemson, returning $400 to $100 bettors. Anyone who has followed his advice is way up.

Now, Nagel has set his sights on Clemson vs. Georgia Tech and just locked in his picks and CFB predictions. You can head to SportsLine now to see Nagel's picks. Here are several college football odds and betting lines for Georgia Tech vs. Clemson:

  • Clemson vs. Georgia Tech spread: Tigers -24
  • Clemson vs. Georgia Tech over/under: 51 points
  • Clemson vs. Georgia Tech money line: Tigers -3500, Yellow Jackets +1350
  • CLEM: Clemson is 28-16-1 ATS in conference games since 2017
  • GT: Georgia Tech is 19-21-1 ATS in its ACC matchups since 2017
  • Clemson vs. Georgia Tech picks: See picks at SportsLine
Featured Game | Georgia Tech Yellow Jackets vs. Clemson Tigers

Why Clemson can cover

The favorite is 5-1-1 against the spread in the past seven meetings, and Clemson has covered the spread in five of its past six games. The Tigers will be looking for a lot more out of Uiagalelei this season after his regression in 2021. He threw for 781 yards and accounted for six TDs in two 2020 starts, which drew Heisman attention entering last season. Then he threw nine TDs and 10 interceptions as the line struggled to protect him. Will Shipley, who scored both TDs in last year's meeting, and fellow running back Kobe Pace can carry the offense if needed. Georgia Tech's defense allowed 184.6 rushing yards per game last season (95th in FBS). 

Shipley and Pace combined for 1,380 rushing yards and 17 TDs, receiver Joseph Ngata averaged 19 yards per reception, and tight end Davis Allen had 28 catches. The heart of the team should be a defense that features a formidable front four. Ends Myles Murphy (seven sacks) and Xavier Thomas (3.5) and tackles Bryan Bresee and Tyler Davis are all top-flight players, and there is quality depth. Bresee, Murphy and linebacker Trenton Simpson all earned preseason All-America mentions. The Tigers are 19-7 ATS in their past 26 neutral-site games.

Why Georgia Tech can cover

Georgia Tech has a standout quarterback in sophomore Jeff Sims, and he is a dual threat who could pose some problems for Clemson if he gets protection. He has 4,213 total yards and 35 TDs in just 17 games (247.8 ypg). Tech went 2-4 and averaged 29 points when he started and was 1-5 and scored just 17 when he didn't. He didn't start last year's meeting, when Tech had three field goals and a safety but held Clemson to two touchdowns. They held Clemson to 126 passing yards and should take confidence from the performance in a tough road environment.

Georgia Tech is 5-1-1 ATS in its past seven at a neutral site, and it should run the ball this season if a more experienced line plays well. Running backs Hassan Hall and Dylan McDuffie both came over as transfers, and McDuffie rushed for 1,049 yards and 11 TDs for Buffalo in 2021. He averaged 5.1 yards per carry, while Hall averaged 4.8 in four seasons at Louisville. Linebackers Ayinde Eley (88 tackles) and Charlie Thomas (70 tackles, three sacks) should have the defense fired up, and the young players around them should benefit from another offseason.    

How to make Georgia Tech vs. Clemson picks

Nagel has analyzed this matchup and while we can tell you he's leaning Under on the point total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Clemson vs. Georgia Tech? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Georgia Tech vs. Clemson picks, all from the expert who is crushing college football, and find out.