Early-season control of the ACC Atlantic Division will be at stake when the 10th-ranked North Carolina State Wolfpack battle the fifth-ranked Clemson Tigers on Saturday. The Wolfpack (4-0), who are opening their league schedule, finished tied for second with Clemson last season with a 6-2 league mark and 9-3 overall record. The Tigers (4-0) are 2-0 in conference play this season after going 10-3 overall in 2021. This will mark the first time the teams have faced each other with both teams ranked in the top 10 and only the fifth time when both teams were ranked.

Kickoff from Memorial Stadium in Clemson, S.C., is set for 7:30 p.m. ET. Clemson leads the all-time series 59-21-1, including a 26-11 edge in games played at Clemson. The Tigers are favored by 6.5 points in the latest North Carolina State vs. Clemson odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. Before making any Clemson vs. NC State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on NC State vs. Clemson and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Clemson vs. NC State:

  • North Carolina State vs. Clemson spread: Clemson -6.5
  • North Carolina State vs. Clemson over/under: 45.5 points 
  • North Carolina State vs. Clemson money line: North Carolina State +215, Clemson -267 
  • NCST: The Wolfpack are 5-2 against the spread in their last seven games against a team with a winning record 
  • CLEM: The Tigers are 20-9 ATS in their last 29 games after scoring more than 40 points in their previous game 
  • North Carolina State vs. Clemson picks: See picks here
Featured Game | Clemson Tigers vs. NC State Wolfpack

Why Clemson can cover

Junior quarterback DJ Uiagalelei, who is looking to improve to 16-4 as a starter, will be attempting to throw for 300 yards in consecutive games for the second time in his career. Last week, he completed 26 of 41 passes (63.4%) for 371 yards and five touchdowns against Wake Forest. He has nine touchdown passes over the past three weeks. For the year, Uiagalelei has thrown for 1,033 yards and 10 touchdowns against one interception.

Defensively, the Tigers are led by junior linebacker Trenton Simpson. Simpson leads Clemson with 27 tackles, including 17 solo. He has at least eight tackles in three different games, and has one pass breakup and one forced fumble. For his career, he has 120 tackles, including 75 solo, with three pass breakups, 10 sacks and two forced fumbles.

Why North Carolina State can cover 

Redshirt junior quarterback Devin Leary has been a big part of the Wolfpack's success. Over the past two seasons, he has posted a 16-3 record as N.C. State's starting quarterback. In 24 starts in his career, he has thrown 60 touchdowns, tied for fourth-best in school history and just three away from entering the top three on the list. Last season, Leary threw a school-record 35 touchdowns, including a league-leading 27 against ACC opponents.

Defensively, the Wolfpack have done a good job of taking away the football. North Carolina State recorded at least two interceptions in each of the first three games of the season. No N.C. State team had accomplished a streak of three consecutive games with two or more interceptions since the final three games of the 2011 season. The Wolfpack's seven interceptions in the first three games this year tied as the fourth-most all-time in school history. The top three for interceptions were in 1998 (10), 1991 (10) and 1960 (eight).

How to make North Carolina State vs. Clemson picks

SportsLine's model is leaning Over on the total, projecting 54 combined points. It has also generated an against-the-spread pick that cashes in more than 60% of simulations. You can only get the model's pick at SportsLine

So who wins North Carolina State vs. Clemson? And which side of the spread cashes in more than 60% of simulations? Visit SportsLine now to see which side of the North Carolina State vs. Clemson spread to jump on, all from the advanced model that finished the past six-plus years up more than $3,100 on its FBS college football picks, and find out.